Chronic myeloid leukaemia with extreme thrombocytosis and T315I BCR-ABL kinase domain mutation : a case report

Abstract EN

Thrombocytosis is a common feature of myeloproliferative neoplasms, including Philadelphia chromosome-positive chronic myeloid leukaemia.

However, symptomatic extreme thrombocytosis causing thrombotic and/or haemorrhagic events is uncommon during the chronic phase of chronic myeloid leukaemia, especially when compared to Philadelphia chromosome-negative myeloproliferative neoplasms like polycythemia vera and essential thrombocythemia.

We report a case of chronic myeloid leukaemia with a complicated clinical course.

The patient did not show a molecular response to imatinib, a tyrosine kinase inhibitor, and was eventually admitted to the hematology/oncology department of King Hussein Medical Center with extreme thrombocytosis, prompting urgent plateletpheresis.

Upon further investigation, molecular analysis to search for ABL kinase domain mutations revealed a po