Endothelial function and subclinical atherosclerosis in patients of chronic obstructive pulmonary disease

Joint Authors

Bellad, Adarshkumar
Raina, Rajiv
Asotra, Sanjeev
Sarkar, Malay
Appajigol, Jayaprakash S
Sharma, Ashok

Source

Journal of the Bahrain Medical Society

Issue

Vol. 32, Issue 1 (31 Mar. 2020), pp.3-8, 6 p.

Publisher

Bahrain Medical Society

Publication Date

2020-03-31

Country of Publication

Bahrain

No. of Pages

6

Main Topic

Medicine

Abstract EN

Background: Chronic Obstructive Pulmonary Disease (COPD) has systemic consequences, including cardiovascular disease.

The endothelial functions are impaired in COPD patients, correlating with the severity of the disease.

Our study is designed to examine the endothelial function in COPD patients by studying Flow Mediated Dilatation (FMD) and its correlation to severity of disease.

Methods: Patients more than 35 years of age with stable COPD were included in the study.

Focused examination was carried out to record blood pressure, ankle brachial index and signs of heart failure.

Detailed biochemical investigations were done along with ECG, Chest X-ray, Spirometry, FMD and carotid intima media thickness in all patients.

Age and sex matched healthy subjects without any evidence of systemic disease were recruited as controls.

Results: Fifty-nine consecutive COPD patients along with their age and sex matched controls were evaluated.

Of the 118 patients, 06 (10.2%) in control group had carotid plaque, while 26 (44.1%) patients in the COPD group were observed to have carotid plaque (p<0.0001).

Mean FMD in the control group was 13.765±4.428 and among COPD patients was 5.7440±3.2698 (p<0.0001).

Conclusions: Endothelial dysfunction measured by FMD was independently associated with Forced Expiratory Volume in the first second (FEV1) i.e., severity of COPD.

We also found that there was higher likelihood of subclinical atherosclerosis and peripheral vascular disease to be present in COPD patients.

Hence, cardiovascular risk factors should be evaluated in all COPD patients.

American Psychological Association (APA)

Bellad, Adarshkumar& Raina, Rajiv& Asotra, Sanjeev& Sharma, Ashok& Sarkar, Malay& Appajigol, Jayaprakash S. 2020. Endothelial function and subclinical atherosclerosis in patients of chronic obstructive pulmonary disease. Journal of the Bahrain Medical Society،Vol. 32, no. 1, pp.3-8.
https://search.emarefa.net/detail/BIM-957973

Modern Language Association (MLA)

Bellad, Adarshkumar…[et al.]. Endothelial function and subclinical atherosclerosis in patients of chronic obstructive pulmonary disease. Journal of the Bahrain Medical Society Vol. 32, no. 1 (2020), pp.3-8.
https://search.emarefa.net/detail/BIM-957973

American Medical Association (AMA)

Bellad, Adarshkumar& Raina, Rajiv& Asotra, Sanjeev& Sharma, Ashok& Sarkar, Malay& Appajigol, Jayaprakash S. Endothelial function and subclinical atherosclerosis in patients of chronic obstructive pulmonary disease. Journal of the Bahrain Medical Society. 2020. Vol. 32, no. 1, pp.3-8.
https://search.emarefa.net/detail/BIM-957973

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 8

Record ID

BIM-957973