Pathological characteristics of giant cell tumor of bone treated with denosumab

Joint Authors

al-Kawwari, Khalid Muqlah
al-Hilli, Fayiq A.

Source

Bahrain Medical Bulletin

Issue

Vol. 42, Issue 2 (30 Jun. 2020), pp.145-147, 3 p.

Publisher

King Hamad University Hospital

Publication Date

2020-06-30

Country of Publication

Bahrain

No. of Pages

3

Main Subjects

Medicine

Abstract EN

We present a Giant Cell Tumor of Bone (GCTB) in a patient who presented with pathological fracture of the lower end of the femur.

The patient was treated with Denosumab, an anti-RANKL inhibitor for four weeks followed by intralesional excision, screw reinforcement and bone cementation.

Denosumab prevented the proliferation of stromal cells and osteoclastogenesis of the GCTB leading to its replacement by a fibrohistiocytic lesion (FHL) which has similar microscopic and immunohistochemical reactivity as that of fibrous histiocytoma.

It increased the formation of reactive bone.

The patient was followed up for six months with no recurrence or activity.

We describe and interpret the microscopic and immunohistochemical (IHC) post-Denosumab bone changes and the role of fracture repair and bone cementation in the organization of the FHL.

American Psychological Association (APA)

al-Kawwari, Khalid Muqlah& al-Hilli, Fayiq A.. 2020. Pathological characteristics of giant cell tumor of bone treated with denosumab. Bahrain Medical Bulletin،Vol. 42, no. 2, pp.145-147.
https://search.emarefa.net/detail/BIM-958047

Modern Language Association (MLA)

al-Kawwari, Khalid Muqlah& al-Hilli, Fayiq A.. Pathological characteristics of giant cell tumor of bone treated with denosumab. Bahrain Medical Bulletin Vol. 42, no. 2 (Jun. 2020), pp.145-147.
https://search.emarefa.net/detail/BIM-958047

American Medical Association (AMA)

al-Kawwari, Khalid Muqlah& al-Hilli, Fayiq A.. Pathological characteristics of giant cell tumor of bone treated with denosumab. Bahrain Medical Bulletin. 2020. Vol. 42, no. 2, pp.145-147.
https://search.emarefa.net/detail/BIM-958047

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 147

Record ID

BIM-958047