Immunomodulating effects of isoprinosine in vaccinated rabbit
Joint Authors
Ahmad, Ahmad Abduh Said
Shams, G. E. A. M.
Idris, Najah al-Sayyid Muhammad Umar
Lutfi, A. M.
Source
Suez Canal Veterinary Medicine Journal
Issue
Vol. 24, Issue 1 (30 Jun. 2019), pp.123-143, 21 p.
Publisher
Suez Canal University Faculty of Veterinary Medicine
Publication Date
2019-06-30
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
The object of this study was to investigate the effects of oral administration of Isoprinosine (163.3mg/ kg) for 21 days, in rabbit before vaccination with (RHVD) vaccine on cellular and humoral immune response.
Forty rabbits were divided into four equal groups.
1st group was left without treatment and used as control, 2nd group was treated with oral dose of isoprinosine (163.3 mg/kg) for 21 days, 3rd group was vaccinated with rabbit haemorrhagic viral disease (RHVD) vaccine and the 4th group was orally administered with isoprinosine (163.3 mg/kg) for 21 days then was vaccinated with (RHVD) vaccine.
Results proved that vaccinated treated rabbits showed a significant improvement in phagocytic percent, phagocytic index, lysozyme activity, nitric oxide, serum total protein, serum albumin, gamma globulins in comparison with vaccinated non-treated rabbits.
DNA destruction percent observed in liver and kidney tissue samples of treated, vaccinated and treated vaccinated groups.
In conclusion, it appears that isoprinosine improves the cellular immune response in vaccinated rabbits and it has a genotoxic effect on hepatocytes of vaccinated rabbits.
American Psychological Association (APA)
Ahmad, Ahmad Abduh Said& Shams, G. E. A. M.& Idris, Najah al-Sayyid Muhammad Umar& Lutfi, A. M.. 2019. Immunomodulating effects of isoprinosine in vaccinated rabbit. Suez Canal Veterinary Medicine Journal،Vol. 24, no. 1, pp.123-143.
https://search.emarefa.net/detail/BIM-958687
Modern Language Association (MLA)
Ahmad, Ahmad Abduh Said…[et al.]. Immunomodulating effects of isoprinosine in vaccinated rabbit. Suez Canal Veterinary Medicine Journal Vol. 24, no. 1 (2019), pp.123-143.
https://search.emarefa.net/detail/BIM-958687
American Medical Association (AMA)
Ahmad, Ahmad Abduh Said& Shams, G. E. A. M.& Idris, Najah al-Sayyid Muhammad Umar& Lutfi, A. M.. Immunomodulating effects of isoprinosine in vaccinated rabbit. Suez Canal Veterinary Medicine Journal. 2019. Vol. 24, no. 1, pp.123-143.
https://search.emarefa.net/detail/BIM-958687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 139-143
Record ID
BIM-958687