Immunomodulating effects of isoprinosine in vaccinated rabbit

Joint Authors

Ahmad, Ahmad Abduh Said
Shams, G. E. A. M.
Idris, Najah al-Sayyid Muhammad Umar
Lutfi, A. M.

Source

Suez Canal Veterinary Medicine Journal

Issue

Vol. 24, Issue 1 (30 Jun. 2019), pp.123-143, 21 p.

Publisher

Suez Canal University Faculty of Veterinary Medicine

Publication Date

2019-06-30

Country of Publication

Egypt

No. of Pages

21

Main Subjects

Veterinary Medicine

Abstract EN

The object of this study was to investigate the effects of oral administration of Isoprinosine (163.3mg/ kg) for 21 days, in rabbit before vaccination with (RHVD) vaccine on cellular and humoral immune response.

Forty rabbits were divided into four equal groups.

1st group was left without treatment and used as control, 2nd group was treated with oral dose of isoprinosine (163.3 mg/kg) for 21 days, 3rd group was vaccinated with rabbit haemorrhagic viral disease (RHVD) vaccine and the 4th group was orally administered with isoprinosine (163.3 mg/kg) for 21 days then was vaccinated with (RHVD) vaccine.

Results proved that vaccinated treated rabbits showed a significant improvement in phagocytic percent, phagocytic index, lysozyme activity, nitric oxide, serum total protein, serum albumin, gamma globulins in comparison with vaccinated non-treated rabbits.

DNA destruction percent observed in liver and kidney tissue samples of treated, vaccinated and treated vaccinated groups.

In conclusion, it appears that isoprinosine improves the cellular immune response in vaccinated rabbits and it has a genotoxic effect on hepatocytes of vaccinated rabbits.

American Psychological Association (APA)

Ahmad, Ahmad Abduh Said& Shams, G. E. A. M.& Idris, Najah al-Sayyid Muhammad Umar& Lutfi, A. M.. 2019. Immunomodulating effects of isoprinosine in vaccinated rabbit. Suez Canal Veterinary Medicine Journal،Vol. 24, no. 1, pp.123-143.
https://search.emarefa.net/detail/BIM-958687

Modern Language Association (MLA)

Ahmad, Ahmad Abduh Said…[et al.]. Immunomodulating effects of isoprinosine in vaccinated rabbit. Suez Canal Veterinary Medicine Journal Vol. 24, no. 1 (2019), pp.123-143.
https://search.emarefa.net/detail/BIM-958687

American Medical Association (AMA)

Ahmad, Ahmad Abduh Said& Shams, G. E. A. M.& Idris, Najah al-Sayyid Muhammad Umar& Lutfi, A. M.. Immunomodulating effects of isoprinosine in vaccinated rabbit. Suez Canal Veterinary Medicine Journal. 2019. Vol. 24, no. 1, pp.123-143.
https://search.emarefa.net/detail/BIM-958687

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 139-143

Record ID

BIM-958687