Treatment of oral squamous cell carcinoma using thymoquinone loaded on gold nanoparticles
Joint Authors
al-Mansi, Mirhan N.
al-Husari, Wafa Husayn Hasanayn
Hasan, Majidah Muhammad Ali
Abu al-Nur, Khulud M.
Source
Suez Canal University Medical Journal
Issue
Vol. 20, Issue 1 (30 Jun. 2017), pp.11-19, 9 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2017-06-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background: Oral cancer is one of the most prevalent cancers.
Thymoquinone has a potential therapeutic activity against cancer cells.
Aim: to compare the effect ofthymoquinone and thymoquinone loaded on gold nanoparticles (GNPs-TQ) as systemic therapeutic agents through intraperitoneal injection for 3&6 weeks after painting of with DMBA 3 times/week for 14w.
Material and Methods: This study was carried out on ninety male Syrian golden hamsters (n=90), its age ranged from 6 to 7 weeks, weighting 90-110 gm, purchased from Theodore Blhars Research Institute, Cairo, Egypt.
Characterization of GNPs was achieved through using Ultraviolet-Visible spectroscope and transmission electron microscope (TEM).
Tissue samples were examined through routine H&E stain, and nuclear factor kappa B cells (NF-κB) immunoreactivity.
Results: Formation of spherical and well dispersed gold nanoparticles (GNPs) (27nm).
Histopathological evaluation showed retardation of carcinogenesis in hamster buccal pouch and regeneration of striated muscle layers when treated with thymoquinone loaded on gold nanoparticles (GNPs-TQ).
These observations were in line with decrease nuclear factor-kappa B expression.
Conclusions: GNPs-TQ is a promising chemo-therapeutic agentin regression of carcinogenesis, and improving the general animal health.
American Psychological Association (APA)
al-Mansi, Mirhan N.& Hasan, Majidah Muhammad Ali& Abu al-Nur, Khulud M.& al-Husari, Wafa Husayn Hasanayn. 2017. Treatment of oral squamous cell carcinoma using thymoquinone loaded on gold nanoparticles. Suez Canal University Medical Journal،Vol. 20, no. 1, pp.11-19.
https://search.emarefa.net/detail/BIM-958719
Modern Language Association (MLA)
al-Mansi, Mirhan N.…[et al.]. Treatment of oral squamous cell carcinoma using thymoquinone loaded on gold nanoparticles. Suez Canal University Medical Journal Vol. 20, no. 1 (2017), pp.11-19.
https://search.emarefa.net/detail/BIM-958719
American Medical Association (AMA)
al-Mansi, Mirhan N.& Hasan, Majidah Muhammad Ali& Abu al-Nur, Khulud M.& al-Husari, Wafa Husayn Hasanayn. Treatment of oral squamous cell carcinoma using thymoquinone loaded on gold nanoparticles. Suez Canal University Medical Journal. 2017. Vol. 20, no. 1, pp.11-19.
https://search.emarefa.net/detail/BIM-958719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 18-19
Record ID
BIM-958719