Effect of different nanothymoquinone concentrations on the chemically-induced epithelial dysplasia in the hamster buccal pouch
Joint Authors
al-Shirbini, Randah H.
Qurrah, Ahmad M.
Hasan, Majidah Muhammad Ali
Source
Suez Canal University Medical Journal
Issue
Vol. 20, Issue 1 (30 Jun. 2017), pp.75-88, 14 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2017-06-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background: Thymoquinone (TQ), an active component of Nigella sativa, has been shown to reduce tumor growth in oral cancer models.
However, toxicity at high doses with poor water solubility limits its usage as a therapeutic agent.
Nanoformulations were introduced to overcome these problems.
Aim: The present study was designed to evaluate the effect of different nanothymoquinone (NTQ) concentrations on the chemically-induced epithelial dysplasia of the hamster buccal pouch.
Materials and Methods: NTQ was prepared to improve the effectiveness of TQ.
Transmission electron microscopy confirmed the particle diameter between 6 to 15 nm.
Clinical observations, histopathological alterations and complete blood count were used to investigate the effect of TQ and NTQ on severe oral epithelial dysplasia induced on hamsters’ buccal pouches by 7,12-dimethylbenz[a]anthracene (DMBA).
Animals received DMBA, three times weekly for six weeks then were treated with intraperitoneal injection of TQ (0.1 mg/kg) or different concentrations of NTQ (0.1, 0.05, 0.025 and 0.01 mg/kg) three times per week for another 6 weeks.
Results: TQand higher concentrations of NTQhad higher anti-tumor activity towards the severe epithelial dysplasia.
The best result was with NTQ 0.1mg/kg concentration.
Conclusion: NTQ is a promising candidate in cancer chemoprevention and chemotherapy as well as striated muscle regeneration.
American Psychological Association (APA)
al-Shirbini, Randah H.& Hasan, Majidah Muhammad Ali& Qurrah, Ahmad M.. 2017. Effect of different nanothymoquinone concentrations on the chemically-induced epithelial dysplasia in the hamster buccal pouch. Suez Canal University Medical Journal،Vol. 20, no. 1, pp.75-88.
https://search.emarefa.net/detail/BIM-958731
Modern Language Association (MLA)
al-Shirbini, Randah H.…[et al.]. Effect of different nanothymoquinone concentrations on the chemically-induced epithelial dysplasia in the hamster buccal pouch. Suez Canal University Medical Journal Vol. 20, no. 1 (2017), pp.75-88.
https://search.emarefa.net/detail/BIM-958731
American Medical Association (AMA)
al-Shirbini, Randah H.& Hasan, Majidah Muhammad Ali& Qurrah, Ahmad M.. Effect of different nanothymoquinone concentrations on the chemically-induced epithelial dysplasia in the hamster buccal pouch. Suez Canal University Medical Journal. 2017. Vol. 20, no. 1, pp.75-88.
https://search.emarefa.net/detail/BIM-958731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 85-88
Record ID
BIM-958731