Development of gabapentin expandable gastroretentive controlled drug delivery system
Other Title(s)
تطوير نظام دوائي ثابت الإفراز قابل للتوسع متواجد في المعدة لفترة طويلة يحتوي على مادة الجابابنتين
Dissertant
Thesis advisor
University
Birzeit University
Faculty
Faculty of Pharmacy, Nursing and Health Professions
University Country
Palestine (West Bank)
Degree
Master
Degree Date
2019
English Abstract
Expandable drug delivery systems are one of many gastroretentive delivery systems which have emerged during the last few years.
Expandable systems are usually folded in a capsule and expand to dimensions greater than the pyloric sphincter upon contact with gastric fluid.
This prevents them from being evacuated by gastric emptying.
The main objective of developing such systems is to increase the residence time of a specific drug in stomach; controlling its release, increasing its bioavailability and patient’s compliance, decreasing its side effects and dosing frequency.
An expandable gastroretentive drug delivery system containing Gabapentin was developed using experimental design.
Compared to the multi layered Accordion PillTM system, the developed system was able to expand to the required dimensions and obtain controlled release of the drug using one layer instead of three or more layers.
This system was able to unfold at stomach pH in less than 15 minutes and obtain a controlled release of 78.1 ± 4.7 % in 6 hours following first order release kinetic model.
It is rigid in stomach and its rigidity decreases at intestinal pH.
FTIR analysis indicated the occurrence of hydrogen bonding in Gabapentin when present in the developed system.
XRD test results indicated that Gabapentin physical properties changed from crystalline in the typical state to amorphous in the developed system.
Main Subjects
Topics
No. of Pages
81
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Gabapentin.
Chapter Three : Experimental design.
Chapter Four : Performed tests.
Chapter Five : Results and discussion.
Conclusion.
References.
American Psychological Association (APA)
Rimawi, Isam. (2019). Development of gabapentin expandable gastroretentive controlled drug delivery system. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-958897
Modern Language Association (MLA)
Rimawi, Isam. Development of gabapentin expandable gastroretentive controlled drug delivery system. (Master's theses Theses and Dissertations Master). Birzeit University. (2019).
https://search.emarefa.net/detail/BIM-958897
American Medical Association (AMA)
Rimawi, Isam. (2019). Development of gabapentin expandable gastroretentive controlled drug delivery system. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-958897
Language
English
Data Type
Arab Theses
Record ID
BIM-958897
