Association of RS 7903146 (C T) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus in Egyptian patients
Joint Authors
Abd al-Raziq, Nahid Y.
Nassar, Hasna M.
Umar, Siham A.
Wisa, Nifin Ramsis
Source
Suez Canal University Medical Journal
Issue
Vol. 19, Issue 1 (30 Jun. 2016), pp.29-38, 10 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background : Many loci were found to be associated with type 2 diabetes mellitus (T2DM) risk as single nucleotide polymorphism (SNP) at the transcription factor 7-like 2 gene (TCF7L2) locus on chromosome 10q (rs7903146) [C/T].
Aim: Estimation of the asso-ciation of this gene polymorphism with T2DM and its complications in Egyptian popula-tion.
Patients and Methods: This study was done, using 90 Egyptian T2DM patients and 100 controls.
This polymorphism was genotyped by conventional PCR.
Measurement of blood glucose, glycated hemoglobin (HbA1c), lipid profile, and microalbuminuria were performed for the study subjects using standard methods.
Body Mass index and fundus examination for detection of diabetic retinopathy were also done.
Results: The geno-type and allele frequencies in TCF7L2 rs7903146 were nearly the same in the patient and control groups (P > 0.05).Odds Ratio for the high risk allele (T) of (rs7903146) was (OR) = 0.97 with 95 % confidence interval (CI) from 0.61 to 1.54 with the P = 0.9.
Conclusion: The-se data suggest that the TCF7L2 SNP rs7903146 may not significantly contribute to T2DM susceptibility in Egyptian population.
American Psychological Association (APA)
Abd al-Raziq, Nahid Y.& Wisa, Nifin Ramsis& Nassar, Hasna M.& Umar, Siham A.. 2016. Association of RS 7903146 (C T) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus in Egyptian patients. Suez Canal University Medical Journal،Vol. 19, no. 1, pp.29-38.
https://search.emarefa.net/detail/BIM-959121
Modern Language Association (MLA)
Abd al-Raziq, Nahid Y.…[et al.]. Association of RS 7903146 (C T) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus in Egyptian patients. Suez Canal University Medical Journal Vol. 19, no. 1 (2016), pp.29-38.
https://search.emarefa.net/detail/BIM-959121
American Medical Association (AMA)
Abd al-Raziq, Nahid Y.& Wisa, Nifin Ramsis& Nassar, Hasna M.& Umar, Siham A.. Association of RS 7903146 (C T) single nucleotide polymorphism at transcription factor 7 like 2 gene with type 2 diabetes mellitus in Egyptian patients. Suez Canal University Medical Journal. 2016. Vol. 19, no. 1, pp.29-38.
https://search.emarefa.net/detail/BIM-959121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 35-38
Record ID
BIM-959121