Autoimmune neutropenia in chronic liver disease patients with hepatitis C virus at Suez Canal University Hospital
Joint Authors
al-Isawi, Nashwa R.
Jubran, Fikri
Atiyyah, Fadiyah M.
Sulayman, Nashat M.
Source
Suez Canal University Medical Journal
Issue
Vol. 19, Issue 1 (30 Jun. 2016), pp.60-67, 8 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background : Chronic hepatitis C (CHC) continues to be a public health problem in Egypt with data suggesting that its incidence may be increasing.
Hepatitis C virus (HCV) infec-tion has been associated with a variety of extra-hepatic manifestations, including auto-immune disorders.
Aim: To assess the prevalence of autoimmune neutropenia (AIN) in chronic liver disease (CLD) patients with HCV.
Patients and Methods: A case-control de-sign was used to fulfill the study objective.
It was conducted on 60 subjects, divided into 2 groups: group 1 (30 HCV-infected patients with low total leucocytic count [TLC] as a study group) and group 2 (30 HCV-infected patients with normal TLC as a control group).
AIN was evaluated by granulocyte immuno-fluorescence test (GIFT) to detect auto-antibodies against neutrophils in HCV-infected patients presented with neutro-penia.
Results: The mean age of the first group was 49.9±11.6 years, while the mean age of the second group was 52.7±11.3 years.
Male gender was found in 53.3 % of the low TLC group compared to 63.3 % in normal TLC group; Positive GIFT was found in 13.3 % of study group; while none of the control group has positive GIFT.
The significant variables among patients with low TLC included low ANC (OR : 5.0, 95 % CI: 1.5-16.5, low HB (OR: 7.0, 95 % CI: 1.4-35.5), and low PLT count (OR: 15.5, 95 % CI: 3.8-63.3).
Conclusion: AIN is sig-nificantly higher among CHC patients with low TLC compared to normal TLC patients.
American Psychological Association (APA)
Sulayman, Nashat M.& Jubran, Fikri& Atiyyah, Fadiyah M.& al-Isawi, Nashwa R.. 2016. Autoimmune neutropenia in chronic liver disease patients with hepatitis C virus at Suez Canal University Hospital. Suez Canal University Medical Journal،Vol. 19, no. 1, pp.60-67.
https://search.emarefa.net/detail/BIM-959129
Modern Language Association (MLA)
Sulayman, Nashat M.…[et al.]. Autoimmune neutropenia in chronic liver disease patients with hepatitis C virus at Suez Canal University Hospital. Suez Canal University Medical Journal Vol. 19, no. 1 (2016), pp.60-67.
https://search.emarefa.net/detail/BIM-959129
American Medical Association (AMA)
Sulayman, Nashat M.& Jubran, Fikri& Atiyyah, Fadiyah M.& al-Isawi, Nashwa R.. Autoimmune neutropenia in chronic liver disease patients with hepatitis C virus at Suez Canal University Hospital. Suez Canal University Medical Journal. 2016. Vol. 19, no. 1, pp.60-67.
https://search.emarefa.net/detail/BIM-959129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 66-67
Record ID
BIM-959129