Assessment of vitamin D and parathyroid hormone in type 2 diabetes mellitus

Abstract EN

Background : Vitamin D deficiency has been proposed as a risk factor for diabetes melli-tus type 2(DM type 2).

Insulin receptor gene expression and insulin secretion are modu-lated by vitamin D, indicating their role in the pathogenesis and development of DM type 2.

Furthermore, elevated PTH levels may play a role in the etiology of metabolic syndrome (MS), through an association with its individual components or via insulin re-sistance.

Aim :This study aimed to investigate the role of vitamin D and parathyroid hor-mone in glycemic control of DM type 2.

Materials and Methods: The study included 90 participants : 6o patients diagnosed as DM type 2 and 30 healthy age and sex-matched subjects as control.

All studied subjects underwent full history taking and complete physical examination.

Laboratory tests included fasting blood sugar (FBS), HbA1c, lipid profile, vitamin D and parathyroid hormone serum levels.

Results: As regard 25(OH) vit-amin D levels, 78.33 % of patients were deficient or insufficient, compared to 20 % of con-trol subjects that were deficient or insufficient.

25(OH) vitamin D levels showed a signif-icant negative correlation with age (p = 0.002), weight (p =0.0001), BMI (p =0.0001) , FBG (p = 0.0001), HbA1C (p = 0.0001) and TG (p=0.002).

Along with a significant positive correla-tion with HDL-C (p = 0.0001).

PTH levels showed a significant negative correlation with HDL-c (P = 0.0001), 25(OH) vitamin D (P = 0.001), in addition to a significant positive corre-lation with weight (P = 0.0001), BMI (P = 0.0001), FBG (P = 0.005) and HbA1c (P = 0.0001).

Conclusion: Not only vitamin D but also parathyroid hormone may play a role in glycemic control in patients with DM Type 2.