Assessment of vitamin D and parathyroid hormone in type 2 diabetes mellitus
Joint Authors
al-Zuhayri, Rasha
al-Khamisi, Inas
Abbas, Nifin F.
Source
Suez Canal University Medical Journal
Issue
Vol. 19, Issue 1 (30 Jun. 2016), pp.76-86, 11 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background : Vitamin D deficiency has been proposed as a risk factor for diabetes melli-tus type 2(DM type 2).
Insulin receptor gene expression and insulin secretion are modu-lated by vitamin D, indicating their role in the pathogenesis and development of DM type 2.
Furthermore, elevated PTH levels may play a role in the etiology of metabolic syndrome (MS), through an association with its individual components or via insulin re-sistance.
Aim :This study aimed to investigate the role of vitamin D and parathyroid hor-mone in glycemic control of DM type 2.
Materials and Methods: The study included 90 participants : 6o patients diagnosed as DM type 2 and 30 healthy age and sex-matched subjects as control.
All studied subjects underwent full history taking and complete physical examination.
Laboratory tests included fasting blood sugar (FBS), HbA1c, lipid profile, vitamin D and parathyroid hormone serum levels.
Results: As regard 25(OH) vit-amin D levels, 78.33 % of patients were deficient or insufficient, compared to 20 % of con-trol subjects that were deficient or insufficient.
25(OH) vitamin D levels showed a signif-icant negative correlation with age (p = 0.002), weight (p =0.0001), BMI (p =0.0001) , FBG (p = 0.0001), HbA1C (p = 0.0001) and TG (p=0.002).
Along with a significant positive correla-tion with HDL-C (p = 0.0001).
PTH levels showed a significant negative correlation with HDL-c (P = 0.0001), 25(OH) vitamin D (P = 0.001), in addition to a significant positive corre-lation with weight (P = 0.0001), BMI (P = 0.0001), FBG (P = 0.005) and HbA1c (P = 0.0001).
Conclusion: Not only vitamin D but also parathyroid hormone may play a role in glycemic control in patients with DM Type 2.
American Psychological Association (APA)
al-Khamisi, Inas& Abbas, Nifin F.& al-Zuhayri, Rasha. 2016. Assessment of vitamin D and parathyroid hormone in type 2 diabetes mellitus. Suez Canal University Medical Journal،Vol. 19, no. 1, pp.76-86.
https://search.emarefa.net/detail/BIM-959135
Modern Language Association (MLA)
al-Khamisi, Inas…[et al.]. Assessment of vitamin D and parathyroid hormone in type 2 diabetes mellitus. Suez Canal University Medical Journal Vol. 19, no. 1 (2016), pp.76-86.
https://search.emarefa.net/detail/BIM-959135
American Medical Association (AMA)
al-Khamisi, Inas& Abbas, Nifin F.& al-Zuhayri, Rasha. Assessment of vitamin D and parathyroid hormone in type 2 diabetes mellitus. Suez Canal University Medical Journal. 2016. Vol. 19, no. 1, pp.76-86.
https://search.emarefa.net/detail/BIM-959135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 83-86
Record ID
BIM-959135