Assessment of the level of soluble CD25 as a marker for the detection of hepatocellular carcinoma in chronic hepatitis c virus (HCV) infected patients
Joint Authors
Wagrees, Shirin Z.
Abd al-Aziz, Hana F.
Badr al-Din, Basmah
Umar, Siham A.
Source
Suez Canal University Medical Journal
Issue
Vol. 21, Issue 2 (31 Dec. 2018), pp.99-106, 8 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2018-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background : Hepatitis C virus (HCV) is one of the most potential pathogens all over the world.
Egypt has the highest HCV prevalence in the world.
The hepatocellular carcinoma (HCC) is among cancers with the poorest outlook.
The detection of HCC improves the outcome.
The poor sensitivity of AFP underlines the need for a biomarker that can detect HCC.
It was found that the CD25 is increased in patients with HCC.
Aim: To assess the performance of serum soluble CD25 (sCD25) in the prediction of early HCC and compare it to α-fetoprotein (AFP); the classical biomarker of HCC.
Patients and Methods: This study was a descriptive study.
Patients were recruited from the Hepatology and Gastro-enterology department at Suez Canal University hospital.
The study included 60 subjects, normal healthy individuals (n = 20), cirrhotic patients (n = 20) and HCC patients (n = 20).
2 blood samples were collected from each patient one for liver profile and second stored for sCD25.
Liver function tests, AFP and sCD25 were done to all the participants.
Results: Our results show a highly significant increased levels of sCD25 in patients with cirrhotic liver and HCC compared to normal controls, (p = 0.001).
No difference was found in sCD25 levels in HCC patients compared to liver cirrhosis patients (p = 0.862).
Conclusion: sCD25 can differentiate HCC patients from normal healthy persons but not from cirrhotic patients.
Thus, sCD25 cannot be used as an accurate diagnostic marker for HCC.
American Psychological Association (APA)
Wagrees, Shirin Z.& Abd al-Aziz, Hana F.& Badr al-Din, Basmah& Umar, Siham A.. 2018. Assessment of the level of soluble CD25 as a marker for the detection of hepatocellular carcinoma in chronic hepatitis c virus (HCV) infected patients. Suez Canal University Medical Journal،Vol. 21, no. 2, pp.99-106.
https://search.emarefa.net/detail/BIM-959155
Modern Language Association (MLA)
Wagrees, Shirin Z.…[et al.]. Assessment of the level of soluble CD25 as a marker for the detection of hepatocellular carcinoma in chronic hepatitis c virus (HCV) infected patients. Suez Canal University Medical Journal Vol. 21, no. 2 (2018), pp.99-106.
https://search.emarefa.net/detail/BIM-959155
American Medical Association (AMA)
Wagrees, Shirin Z.& Abd al-Aziz, Hana F.& Badr al-Din, Basmah& Umar, Siham A.. Assessment of the level of soluble CD25 as a marker for the detection of hepatocellular carcinoma in chronic hepatitis c virus (HCV) infected patients. Suez Canal University Medical Journal. 2018. Vol. 21, no. 2, pp.99-106.
https://search.emarefa.net/detail/BIM-959155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 105-106
Record ID
BIM-959155