Evaluation of vitamin D levels in women with Carpal tunnel syndrome

Abstract EN

Background: For decades, the role of vitamin D was limited to the formation and maintenance of bone as well as homeostasis of calcium and phosphate.

Vitamin D is a steroid molecule, mainly synthesized in the skin from 7 dehydro cholesterol by ultraviolet irradiation or obtained through the diet.

The major circulating metabolite of vitamin D is 25(OH) Vitamin D (25(OH)D), with a halflife of 21–30 days.

Serum concentration of 25(OH) D is the most reliable biochemical index of vitamin status.

Aim: The goal of the present study was to investigate the relationship between vitamin D levels and carpal tunnel syndrome (CTS) Patients and Methods: This study included 50 female patients with mild to moderate CTS and assessed their serum 25-hydroxyvitamin D levels.

We included patients with a diagnosis of CTS based on both the clinical symptoms and positive neurophysiology.

Controls (electrophysiological negative symptomatic patients) were evaluated 50 patients matched with sex and age clinically by rheumatologist.

Results: the mean age of patients with CTS symptoms and control group were 49.2 ± 10.6 (range 21–54) and 49.7 ± 10.6 (range 20–55), respectively, with no significant difference between the two groups (p = 0.534).

Patients with CTS symptoms had significantly lower 25(OH) D levels compared to controls.

There’s significance difference among the CTS patient regarding Boston Carpal Tunnel Questionnaire (BQ).

Conclusion: a potential link between vitamin D status and the occurrence of CTS is suggested.