Oxidative stress status in patients with rheumatoid arthritis
Other Title(s)
حالة الأكسدة في مرضى التهاب المفاصل الرثوي
Joint Authors
Qasim, Muhammad Naji
Mahdi, Jawad Kazim
Jawad, Abd al-Karim Muhammad
Source
Issue
Vol. 16, Issue 2 (31 Dec. 2018), pp.21-29, 9 p.
Publisher
University of Thi-Qar College of Medicine
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
Background:Rheumatoid arthritis (RA) is the most common form of inflammatory arthritis, which is an autoimmune disease characterized by chronic inflammation of synovial joints, ultimately leading to joint destructions and permanent disability.In RA oxidative stress are impaired (which caused by free radicals) might have an essential role in the etiology of RA.
Objectives:The objective of this study was to determine oxidative stress by measuring malondialdehyde and enzymatic status by estimating superoxide dismutase, catalase and glutathione peroxidase in patients of RA and then comparing with healthy individuals.Setting and design: A total 42 patients with Rheumatoid Arthritis (20 females, 22 males) in the age of 30-50 years were included, as a control, 50 matched healthy volunteers (20 females and 30 males) were involve, non of the subjects smokes nor receiving any form of drugs.
Subjects with any acute infections or with coexisting system disease such as coronary artery disease, hypertension or chronic renal failure were excluded.
Methods: Antioxidant enzymes in erythrocyte , superoxide dismutase (SOD), glutathione peroxidase (Gpx) and Cayalase (CAT) was measured.
Malondialdehyde (MDA) along with Copper, Zink and Iron are measured by using the serum of the patients and control group.Results: The serum level of MDL was higher in RA patients compared with the control group, the differences among both groups was statistically significant (P < 0.001)ConclusionThere is oxidative stress in RA patients evidenced by increased serum MDA and decreased antioxidant enzymes activity.
American Psychological Association (APA)
Mahdi, Jawad Kazim& Jawad, Abd al-Karim Muhammad& Qasim, Muhammad Naji. 2018. Oxidative stress status in patients with rheumatoid arthritis. Thi-Qar Medical Journal،Vol. 16, no. 2, pp.21-29.
https://search.emarefa.net/detail/BIM-960878
Modern Language Association (MLA)
Mahdi, Jawad Kazim…[et al.]. Oxidative stress status in patients with rheumatoid arthritis. Thi-Qar Medical Journal Vol. 16, no. 2 (2018), pp.21-29.
https://search.emarefa.net/detail/BIM-960878
American Medical Association (AMA)
Mahdi, Jawad Kazim& Jawad, Abd al-Karim Muhammad& Qasim, Muhammad Naji. Oxidative stress status in patients with rheumatoid arthritis. Thi-Qar Medical Journal. 2018. Vol. 16, no. 2, pp.21-29.
https://search.emarefa.net/detail/BIM-960878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 25-28
Record ID
BIM-960878