Evaluation of antipsoriatic activity of topical curcumin by using mouse tail model

Abstract EN

Background; Psoriasis is a one of the common dermatological diseases with no curative topical or systemic treatment, Curcumin is a naturally occurring phytochemical present in turmeric; it was traditionally used for the treatment of many skin diseases.

This study was designed to evaluate the anti-psoriatic effect of curcumin preparations.

Objectives; this study aimed to examine the probability of anti-psoriatic activity of topical curcumin by using mouse tail model.Methods; The extracted curcumin was assessed for antipsoriatic activity using a mouse tail model of psoriasis.

18 animals were divided into three groups (6 animals each).Group A: control group (cream base treated group)Group B: (treated with curcumin cream 1%)Group C: (treated with curcumin cream 2 %)Granular layer formation, epidermal thickness and drug activity were taken as an evaluating parameter to detect the efficacy of the new preparation.Results; The local application of curcumin 1%, 2% on the mouse tail skin produced a significant differentiation in the epidermis, as seen from its degree of orthokeratosis ( 43.4± 0.75) and ( 44.4 ±0.98 ) respectively when compared with the negative control (17.06±2.5 ).Conclusion;Topical curcumin have anti-psoriatic activity and seems to be well tolerated on skin since the incidence of side effects was limited except staining of skin by an orange color.