Effect of liver diseases on hormonal and biochemical parameters in Wistar albino rat
Joint Authors
Kamal, H. H.
Ahmad, Wala M. S.
Said, Hanan E.
Muhammad, Amirah H.
Source
Journal of Veterinary Medical Research
Issue
Vol. 24, Issue 2 (31 Mar. 2018)19 p.
Publisher
Beni-Suef University Faculty of Veterinary Medicine
Publication Date
2018-03-31
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
The current study was performed to evaluate the effect of acute and chronic hepatotoxicity induced by paracetamol and thioacetamide respectively on serum hormonal levels and biochemical parameters.
Female Wistar albino rats were divided into 3 equal groups (C), (P) and (T).
Group (C) were kept as control, group (P) were received paracetamol orally (500 mg/kg b.wt) daily for 15 days and those of group (T) were injected thioacetamide (200 mg/kg b.wt) intraperitonialy twice/ week for 90 days.
In P group, results revealed significant elevation in liver enzyme activities (ALT, AST and ALP), T4, insulin (7th day), estrogen (7th and 15th days), triglycerides (7th day) and cholesterol levels throughout the experiment while serum proteins and T4 (15th day) showed significant decreased values.
Whereas, at 90th days of chronic intoxicated group (T) resulted in significant elevation in liver enzyme activities (ALT, AST and ALP), bilirubin, estrogen, T4, triglycerides (60th and 90th days) and T3 (120th day).
While the levels of T4 and cortisol (60th day), serum total protein, albumin, globulin (90th day) and insulin (120th day) showed significant decreased values when compared to control group.
In conclusion, both paracetamol and thioacetamide cause different degrees of damage in liver of rats leading to clear changes in their hormonal and biochemical profiles.
American Psychological Association (APA)
Muhammad, Amirah H.& Kamal, H. H.& Ahmad, Wala M. S.& Said, Hanan E.. 2018. Effect of liver diseases on hormonal and biochemical parameters in Wistar albino rat. Journal of Veterinary Medical Research،Vol. 24, no. 2.
https://search.emarefa.net/detail/BIM-962097
Modern Language Association (MLA)
Muhammad, Amirah H.…[et al.]. Effect of liver diseases on hormonal and biochemical parameters in Wistar albino rat. Journal of Veterinary Medical Research Vol. 24, no. 2 (2018).
https://search.emarefa.net/detail/BIM-962097
American Medical Association (AMA)
Muhammad, Amirah H.& Kamal, H. H.& Ahmad, Wala M. S.& Said, Hanan E.. Effect of liver diseases on hormonal and biochemical parameters in Wistar albino rat. Journal of Veterinary Medical Research. 2018. Vol. 24, no. 2.
https://search.emarefa.net/detail/BIM-962097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-962097