Letrozole and anastrozole in early breast cancer post-menopausal patients in oncology department at Suez Canal University Hospital
Joint Authors
Muntasir, Manar
Abd al-Muhsin, Suhayr E.
Zamzam, Maha L.
Hasanayn, Ihab M.
Source
Suez Canal University Medical Journal
Issue
Vol. 21, Issue 1 (30 Jun. 2018), pp.40-49, 10 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2018-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background:There are limited data in the literature comparing the efficacy of aromatase inhibitors in postmenopausal hormonal receptor positive early breast cancer patients.
Aim: To compare the efficacy of letrozole and anastrozole in hormone-receptor positive postmenopausal breast cancer patients.
Patients and Methods: A retrospective study with a mean follow-up period of 64 months (about 5 years) for 74 files of early invasive postmenopausal breast cancer hormonal receptor positive patients; 39 received letrozole and 35 received anastrozole, considering TTP as primary end point, and OS as second end points.
Results: Letrozole is not superior to anastrozole during the first 55 months of treatment (80% PFS at 5th year), and 80% OS benefit at 6th year..
Overweight patients had better (90% PFS at 5th year) than obese patients (60% PFS at 5th year).
Conclusion: Letrozole is not superior to anastrozole in efficacy in early invasive hormonal receptor positive breast cancer postmenopausal patients during the first 5 years of treatment; however, Letrozole 2nd line after tamoxifen is superior to anastrozole 2nd line after tamoxifen in treating obese patients with early invasive hormone receptor positive breast cancer.
American Psychological Association (APA)
Muntasir, Manar& Hasanayn, Ihab M.& Abd al-Muhsin, Suhayr E.& Zamzam, Maha L.. 2018. Letrozole and anastrozole in early breast cancer post-menopausal patients in oncology department at Suez Canal University Hospital. Suez Canal University Medical Journal،Vol. 21, no. 1, pp.40-49.
https://search.emarefa.net/detail/BIM-963678
Modern Language Association (MLA)
Muntasir, Manar…[et al.]. Letrozole and anastrozole in early breast cancer post-menopausal patients in oncology department at Suez Canal University Hospital. Suez Canal University Medical Journal Vol. 21, no. 1 (2018), pp.40-49.
https://search.emarefa.net/detail/BIM-963678
American Medical Association (AMA)
Muntasir, Manar& Hasanayn, Ihab M.& Abd al-Muhsin, Suhayr E.& Zamzam, Maha L.. Letrozole and anastrozole in early breast cancer post-menopausal patients in oncology department at Suez Canal University Hospital. Suez Canal University Medical Journal. 2018. Vol. 21, no. 1, pp.40-49.
https://search.emarefa.net/detail/BIM-963678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 49
Record ID
BIM-963678