Genetics and pathophysiology of maturity-onset diabetes of the young (MODY)‎ : a review of current trends

Joint Authors

Yahya, Taj al-Din O.
Ufuoma, Shemishere B.

Source

Oman Medical Journal

Issue

Vol. 35, Issue 3 (31 May. 2020)10 p.

Publisher

Oman Medical Specialty Board

Publication Date

2020-05-31

Country of Publication

Oman

No. of Pages

10

Main Topic

Diseases

Topics

Abstract EN

Single gene mutations have been implicated in the pathogenesis of a form of diabetes mellitus (DM) known as the maturity-onset diabetes of the young (MODY).

However, there are diverse opinions on the suspect genes and pathophysiology, necessitating the need to review and communicate the genes to raise public awareness.

We used the Google search engine to retrieve relevant information from reputable sources such as PubMed and Google Scholar.

We identified 14 classified MODY genes as well as three new and unclassified genes linked with MODY.

These genes are fundamentally embedded in the beta cells, the most common of which are HNF1A, HNF4A, HNF1B, and GCK genes.

Mutations in these genes cause β-cell dysfunction, resulting in decreased insulin production and hyperglycemia.

MODY genes have distinct mechanisms of action and phenotypic presentations compared with type 1 and type 2 DM and other forms of DM.

Healthcare professionals are therefore advised to formulate drugs and treatment based on the causal genes rather than the current generalized treatment for all types of DM.

This will increase the effectiveness of diabetes drugs and treatment and reduce the burden of the disease.

American Psychological Association (APA)

Yahya, Taj al-Din O.& Ufuoma, Shemishere B.. 2020. Genetics and pathophysiology of maturity-onset diabetes of the young (MODY) : a review of current trends. Oman Medical Journal،Vol. 35, no. 3.
https://search.emarefa.net/detail/BIM-965097

Modern Language Association (MLA)

Yahya, Taj al-Din O.& Ufuoma, Shemishere B.. Genetics and pathophysiology of maturity-onset diabetes of the young (MODY) : a review of current trends. Oman Medical Journal Vol. 35, no. 3 (May. 2020).
https://search.emarefa.net/detail/BIM-965097

American Medical Association (AMA)

Yahya, Taj al-Din O.& Ufuoma, Shemishere B.. Genetics and pathophysiology of maturity-onset diabetes of the young (MODY) : a review of current trends. Oman Medical Journal. 2020. Vol. 35, no. 3.
https://search.emarefa.net/detail/BIM-965097

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-965097