Detection of CHEK2 1100delC mutation in BRCA-negative individuals from hereditary breast cancer families in Gaza strip

Joint Authors

Hassunah, Isra
al-Manaimah, Mahmud Abd al-Jalil Abd al-Latif

Source

Research

Issue

Vol. 2019, Issue 12 (31 Jan. 2019)7 p.

Publisher

National Research Center

Publication Date

2019-01-31

Country of Publication

Palestine (Gaza Strip)

No. of Pages

7

Main Topic

Diseases

Topics

Abstract EN

Checkpoint kinase (CHEK2) encodes a cell cycle checkpoint kinase that plays an important role in the DNA damage repair pathway , activated mainly by ATM (Ataxia Telangiectasia Mutated) in response to double-stranded DNA breaks.

It is known as a tumor suppressor gene in breast cancer (BC) and have been associated with different types of cancer.

About 5%-10% of all BC are associated with hereditary predisposition and its recognition is of great importance for genetic counseling and cancer risk management.

The present study, we screened 100 non-cancer individuals and 100 incident breast cancer cases for the distribution of CHEK2 1100delc mutation.

We used allele specific PCR in order to detect the mutation.

All cases were compared with controls.

Our data may indicate that 1100delc I157T mutation within CHEK2 gene was absent in BC patients and an elevated risk for genetic susceptibility for BC among Palestinian population are not associated with CHEK2 1100delc

American Psychological Association (APA)

Hassunah, Isra& al-Manaimah, Mahmud Abd al-Jalil Abd al-Latif. 2019. Detection of CHEK2 1100delC mutation in BRCA-negative individuals from hereditary breast cancer families in Gaza strip. Research،Vol. 2019, no. 12.
https://search.emarefa.net/detail/BIM-969224

Modern Language Association (MLA)

Hassunah, Isra& al-Manaimah, Mahmud Abd al-Jalil Abd al-Latif. Detection of CHEK2 1100delC mutation in BRCA-negative individuals from hereditary breast cancer families in Gaza strip. Research No. 12 (Jan. 2019).
https://search.emarefa.net/detail/BIM-969224

American Medical Association (AMA)

Hassunah, Isra& al-Manaimah, Mahmud Abd al-Jalil Abd al-Latif. Detection of CHEK2 1100delC mutation in BRCA-negative individuals from hereditary breast cancer families in Gaza strip. Research. 2019. Vol. 2019, no. 12.
https://search.emarefa.net/detail/BIM-969224

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-969224