Effect of cyclophosphamide treatment during the embryonic period on fertility of adult male mice
Other Title(s)
تأثير عقار السايكلوفوسفاميد خلال المراحل الجنينية على خصوبة ذكور الفئران البيض البالغين
Joint Authors
al-Nuwayhi, Nawras Adnan
al-Rudaini, Amjad Turki
Source
Issue
Vol. 60, Issue 4 (30 Apr. 2019), pp.706-714, 9 p.
Publisher
University of Baghdad College of Science
Publication Date
2019-04-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
The cyclophosphamide is commonly used for the treatment of cancer and immunosuppressive diseases in young and old age and can induce oxidative stress in reproductive organs, therefore has adverse effects on sperm quality and quantity.
In this study, the effects of a single dose of cyclophosphamide on sperm parameters in adult male mice that treated with 10 mg/kg of this drug on the 11th embryonic day were investigated.
Adult female pregnant NMRI mice were divided into 2 groups; the control group received saline and the cyclophosphamide group received cyclophosphamide at a dose of 10 mg / kg on day 11th of gestation (i.p).
60 days after the birth of the infants, male mice were sacrificed and the sperm collected from cauda of epididymis for sperm parameters study.
Cyclophosphamide administration resulted in a decrease in body and testicular weight, viability, motility, and count of sperm (p? 0.05), and an increase in sperm head, neck and tail abnormality (p? 0.05).
It was concluded that the cyclophosphamide, has long-term destructive effects on sperm parameters and these effects can be continuing after puberty.
American Psychological Association (APA)
al-Nuwayhi, Nawras Adnan& al-Rudaini, Amjad Turki. 2019. Effect of cyclophosphamide treatment during the embryonic period on fertility of adult male mice. Iraqi Journal of Science،Vol. 60, no. 4, pp.706-714.
https://search.emarefa.net/detail/BIM-969243
Modern Language Association (MLA)
al-Nuwayhi, Nawras Adnan& al-Rudaini, Amjad Turki. Effect of cyclophosphamide treatment during the embryonic period on fertility of adult male mice. Iraqi Journal of Science Vol. 60, no. 4 (2019), pp.706-714.
https://search.emarefa.net/detail/BIM-969243
American Medical Association (AMA)
al-Nuwayhi, Nawras Adnan& al-Rudaini, Amjad Turki. Effect of cyclophosphamide treatment during the embryonic period on fertility of adult male mice. Iraqi Journal of Science. 2019. Vol. 60, no. 4, pp.706-714.
https://search.emarefa.net/detail/BIM-969243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 712-714
Record ID
BIM-969243