Biomarker significance of serum CXCL8, CXCL10 and CXCL16 in breast tumors of Iraqi patients
Other Title(s)
الأهمية الواسم-حياتية للحركيات الكيميائية المصلية 8 و 10 و 16 لأورام الثدي في مريضات عراقيات
Joint Authors
al-Naqqash, Munawwir Abd al-Ilah
Khalaf, Asil Fakhri
al-Ulwan, Nada Abd al-Sahib
Adhiah, Ali Husayn
Source
Issue
Vol. 17, Issue 1 (sup) (31 Mar. 2020), pp.199-206, 8 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2020-03-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women.
Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation.
The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs.
15.0; CXCL10: 37.6 and 30.7 vs.
13.1; CXCL16; 27.9 and 25.2 vs.
19.2 pg/ml, respectively).
The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively.
Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients.
The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients.
In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered.
In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
American Psychological Association (APA)
Khalaf, Asil Fakhri& al-Naqqash, Munawwir Abd al-Ilah& al-Ulwan, Nada Abd al-Sahib& Adhiah, Ali Husayn. 2020. Biomarker significance of serum CXCL8, CXCL10 and CXCL16 in breast tumors of Iraqi patients. Baghdad Science Journal،Vol. 17, no. 1 (sup), pp.199-206.
https://search.emarefa.net/detail/BIM-970022
Modern Language Association (MLA)
Khalaf, Asil Fakhri…[et al.]. Biomarker significance of serum CXCL8, CXCL10 and CXCL16 in breast tumors of Iraqi patients. Baghdad Science Journal Vol. 17, no. 1 (Supplement) (Mar. 2020), pp.199-206.
https://search.emarefa.net/detail/BIM-970022
American Medical Association (AMA)
Khalaf, Asil Fakhri& al-Naqqash, Munawwir Abd al-Ilah& al-Ulwan, Nada Abd al-Sahib& Adhiah, Ali Husayn. Biomarker significance of serum CXCL8, CXCL10 and CXCL16 in breast tumors of Iraqi patients. Baghdad Science Journal. 2020. Vol. 17, no. 1 (sup), pp.199-206.
https://search.emarefa.net/detail/BIM-970022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 204-205
Record ID
BIM-970022