Spectrophotometric and reverse flow injection method determination of nitrazepam in pharmaceuticals using O-Coumaric acid as a new chromogenic reagent

Other Title(s)

طريقة الحقن الجرياني العكوس و التقدير الطيفي للنايترازيبام في المستحضرات الصيدلانية باستخدام أورثو حامض الكوماريك ككاشف كروموجيني جديد

Author

Hasan, Sadim Subhi Abd

Source

Baghdad Science Journal

Issue

Vol. 17, Issue 1 (sup) (31 Mar. 2020), pp.265-271, 7 p.

Publisher

University of Baghdad College of Science for Women

Publication Date

2020-03-31

Country of Publication

Iraq

No. of Pages

7

Main Subjects

Veterinary Medicine

Abstract EN

A spectrophotometric- reverse flow injection analysis (rFIA) method has been proposed for the determination of Nitrazepam (NIT) in pure and pharmaceutical preparations.

The method is based upon the coupling reaction of NIT with a new reagent O-Coumaric acid (OCA) in the presence of sodium periodate in an aqueous solution.

The blue color product was measured at 632 nm.

The variation (chemical and physical parameters) related with reverse flow system were estimated.

The linearity was over the range 15 - 450 µg/mL of NIT with detection limits and limit of quantification of 3.425 and 11.417 µg mL-1 NIT,respectively.

The sample throughput of 28 samples per hour was achieved.

Suggested method was successfully applied for the determination of NIT in its dosage forms.

American Psychological Association (APA)

Hasan, Sadim Subhi Abd. 2020. Spectrophotometric and reverse flow injection method determination of nitrazepam in pharmaceuticals using O-Coumaric acid as a new chromogenic reagent. Baghdad Science Journal،Vol. 17, no. 1 (sup), pp.265-271.
https://search.emarefa.net/detail/BIM-970030

Modern Language Association (MLA)

Hasan, Sadim Subhi Abd. Spectrophotometric and reverse flow injection method determination of nitrazepam in pharmaceuticals using O-Coumaric acid as a new chromogenic reagent. Baghdad Science Journal Vol. 17, no. 1 (Supplement) (Mar. 2020), pp.265-271.
https://search.emarefa.net/detail/BIM-970030

American Medical Association (AMA)

Hasan, Sadim Subhi Abd. Spectrophotometric and reverse flow injection method determination of nitrazepam in pharmaceuticals using O-Coumaric acid as a new chromogenic reagent. Baghdad Science Journal. 2020. Vol. 17, no. 1 (sup), pp.265-271.
https://search.emarefa.net/detail/BIM-970030

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 270-271

Record ID

BIM-970030