The study of the effect of sodium nitroprusside in anxiety-like behavior in mice in comparison with diazepam

Other Title(s)

دراسة تأثير صوديوم نايتروبروسايد في السلوك المماثل للقلق في الفئران بالمقارنة مع الدايازيبام

Joint Authors

al-Humaydi, Abir Muzaffar
Hulayyil, Afrah Dhiyab
Shallal, Sima Hasan

Source

Iraqi Journal of Science

Issue

Vol. 61, Issue 3 (31 Mar. 2020), pp.485-490, 6 p.

Publisher

University of Baghdad College of Science

Publication Date

2020-03-31

Country of Publication

Iraq

No. of Pages

6

Main Topic

Chemistry
Pharmacology

Abstract EN

Anxiety has become a highly paramount field of research attention in psychopharmacology today.

Sundry studies have shown a nitric oxide role in the regulation of anxiety.

The goal of the study was to investigate sodium nitroprusside ability to affect anxiety-like behavior in mice and to compare this effect with the standard anxiolytic drug, diazepam, using both plus maze test and light/dark box test.

The results revealed that sodium nitroprusside at a dose of 1 mg/kg had a significant effect on the behavior in both of the elevated plus maze test and light/dark test.

However, at higher dose (3 mg/kg), it has significantly increased the anxiogenic-like effect in the light/dark box test.

Diazepam at a dose of 2 mg/kg increased the time spent in open arms in elevated plus maze test and that in light chambers of light/dark test.

These outcomes suggest that a nitric oxide pathway seems to play an important role in anxiety.

Furthermore, sodium nitroprusside at a dose of 1 mg/kg showed a nearly anxiolytic ability, when compared with diazepam.

American Psychological Association (APA)

al-Humaydi, Abir Muzaffar& Hulayyil, Afrah Dhiyab& Shallal, Sima Hasan. 2020. The study of the effect of sodium nitroprusside in anxiety-like behavior in mice in comparison with diazepam. Iraqi Journal of Science،Vol. 61, no. 3, pp.485-490.
https://search.emarefa.net/detail/BIM-970051

Modern Language Association (MLA)

al-Humaydi, Abir Muzaffar…[et al.]. The study of the effect of sodium nitroprusside in anxiety-like behavior in mice in comparison with diazepam. Iraqi Journal of Science Vol. 61, no. 3 (2020), pp.485-490.
https://search.emarefa.net/detail/BIM-970051

American Medical Association (AMA)

al-Humaydi, Abir Muzaffar& Hulayyil, Afrah Dhiyab& Shallal, Sima Hasan. The study of the effect of sodium nitroprusside in anxiety-like behavior in mice in comparison with diazepam. Iraqi Journal of Science. 2020. Vol. 61, no. 3, pp.485-490.
https://search.emarefa.net/detail/BIM-970051

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 489-490

Record ID

BIM-970051