Monitoring of the immune response activity in Iraqi patients infected with cutaneous leishmaniasis by IFN-γ and MIG evaluation during different stages of infection

Other Title(s)

متابعة فعالية الاستجابة المناعية في المرضى العراقيين المصابين باللشمانيا الجلدية بواسطة تقييم خلال مراحل المرض المختلفة IFN-γ و MIG

Joint Authors

Jamil, Rim Ala al-Din
al-Qadi, Ban Nuri

Source

Iraqi Journal of Science

Issue

Vol. 61, Issue 5 (31 May. 2020), pp.970-977, 8 p.

Publisher

University of Baghdad College of Science

Publication Date

2020-05-31

Country of Publication

Iraq

No. of Pages

8

Main Topic

Diseases

Topics

Abstract EN

Cutaneous leishmaniasis (CL) is one of the most prevalent cutaneous parasitic protozoan infections in Iraq; characterized by a chronic infection and granulomatous disease that invades the skin.

Type 1 immune was predominates in CL patients with exacerbated production of pro-inflammatory cytokine, therefore this study aimed to evaluate serum level of interferon gamma (IFN-γ) and monokine induce by interferon gamma (MIG/CXCl9) as a useful markers of disease development in patients during different stage of infection (<1 month ..

early , 1-6 month..

chronic and >6 months..

late).

The result showed that there was an early effort to eliminate the parasite proliferation which illustrated by a high significant increase of both IFN-γ and MIG during the early stage of infection, but this response was down-regulated during the chronic stage of infection, which observed by low levels of both studied cytokine and monokine, nevertheless this down-regulation was transient where the levels to increase returns during the late stage of infection.

The evaluation of IFN-γ and MIG considered as a biological markers of disease activity in each stage of infection.

American Psychological Association (APA)

Jamil, Rim Ala al-Din& al-Qadi, Ban Nuri. 2020. Monitoring of the immune response activity in Iraqi patients infected with cutaneous leishmaniasis by IFN-γ and MIG evaluation during different stages of infection. Iraqi Journal of Science،Vol. 61, no. 5, pp.970-977.
https://search.emarefa.net/detail/BIM-970205

Modern Language Association (MLA)

Jamil, Rim Ala al-Din& al-Qadi, Ban Nuri. Monitoring of the immune response activity in Iraqi patients infected with cutaneous leishmaniasis by IFN-γ and MIG evaluation during different stages of infection. Iraqi Journal of Science Vol. 61, no. 5 (2020), pp.970-977.
https://search.emarefa.net/detail/BIM-970205

American Medical Association (AMA)

Jamil, Rim Ala al-Din& al-Qadi, Ban Nuri. Monitoring of the immune response activity in Iraqi patients infected with cutaneous leishmaniasis by IFN-γ and MIG evaluation during different stages of infection. Iraqi Journal of Science. 2020. Vol. 61, no. 5, pp.970-977.
https://search.emarefa.net/detail/BIM-970205

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 976-977

Record ID

BIM-970205