In silico analysis of regulatory elements of the vitamin D receptor
Other Title(s)
تحليل في السليكون للعناصر التنظيمية لجينات مستقبلات فيتامين دي
Joint Authors
Farivar, Shirin
Amiri Nijad, Ruya
Gargari, Bahar Naghavi
Husni, Sayyidah Batul
Shirvani Farsani, Zaynab
Source
Issue
Vol. 17, Issue 2 (30 Jun. 2020), pp.463-470, 8 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2020-06-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
Vitamin D receptor (VDR) is a nuclear transcription factor that controls gene expression.
Its impaired expression was found to be related to different diseases.
VDR also acts as a regulator of different pathways including differentiation, inflammation, calcium and phosphate absorption, etc.
but there is no sufficient knowledge about the regulation of the gene itself.
Therefore, a better understanding of the genetic and epigenetic factors regulating the VDR may facilitate the improvement of strategies for the prevention and treatment of diseases associated with dysregulation of VDR.
In the present investigation, a set of databases and methods were used to identify putative functional elements in the VDR locus.
Histone modifications, CpG Islands, epigenetic marks at VDR locus were indicated.
In addition, repeated sequences, enhancers, insulators, transcription factor binding sites and targets of the VDR gene, as well as protein-protein interactions with bioinformatics tools, were reported.
Some of these genetic elements had overlapped with CpG Islands.
These results revealed important new insight into the molecular mechanisms of the VDR gene regulation in human cells and tissues.
American Psychological Association (APA)
Farivar, Shirin& Amiri Nijad, Ruya& Gargari, Bahar Naghavi& Husni, Sayyidah Batul& Shirvani Farsani, Zaynab. 2020. In silico analysis of regulatory elements of the vitamin D receptor. Baghdad Science Journal،Vol. 17, no. 2, pp.463-470.
https://search.emarefa.net/detail/BIM-970240
Modern Language Association (MLA)
Farivar, Shirin…[et al.]. In silico analysis of regulatory elements of the vitamin D receptor. Baghdad Science Journal Vol. 17, no. 2 (2020), pp.463-470.
https://search.emarefa.net/detail/BIM-970240
American Medical Association (AMA)
Farivar, Shirin& Amiri Nijad, Ruya& Gargari, Bahar Naghavi& Husni, Sayyidah Batul& Shirvani Farsani, Zaynab. In silico analysis of regulatory elements of the vitamin D receptor. Baghdad Science Journal. 2020. Vol. 17, no. 2, pp.463-470.
https://search.emarefa.net/detail/BIM-970240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 468-470
Record ID
BIM-970240