Vitamin D status in children with recurrent wheeze

Abstract EN

Background: it has been shown that low serum 25-hydroxyvitamin D concentration was associated with a higher risk of upper and lower respiratory infections in childrenAim to evaluate vitamin D concentration and selected biochemical markers in infants and children with recurrent wheeze.

Methods: a case-control study has been carried out to measure serum vitamin Concentration; on 33 patients with recurrent wheeze, their ages ranged from 4-60 months; over the period from the1stof March 2014 to the end of June 2014.

Forty-two age and sex matched healthy children were selected as control group.

List of investigation was measured by spectrophotometer as serum calcium, phosphorus, alkaline phosphatase and 25-OH vitamin.

Result: Frequency of breast feeding in the first two years of life was low in wheezy children and significantly shorter duration of breast feeding less than 4 months in wheezy children than control group, P value 0.

01.

Vitamin D concentration was significantly low in children with recurrent wheeze than the control group; (21.

69 ng/ml, 39.

36 ng/ml) respectively with p-value 0.

000.

The severity of vitamin D deficiency was significant in children with recurrent wheeze, severe deficiency of vitamin D < 5 ng/ml recorded in 4(100%), p-value of 0.

001.

while mean serum calcium, phosphorus and alkaline phosphatase shows no significant difference.

There is no significant relation observed between mean Vitamin D concentration and selected variables of infants and children with wheeze (P value > 0.

05)Conclusion: vitamin D supplementation may be considered in infants and children with recurrent wheeze.