Effects of bardoxolone on nuclear factor-erythroid 2-related factor 2 signaling pathway in HCT-116 human colonic cancer cell line : in vitro study
Joint Authors
al-Rikabi, Samir H.
Kammona, Talib H.
Ubayd, Hamid N.
al-Khafaji, Nail Abbas K.
Source
Issue
Vol. 17, Issue 1 (31 Mar. 2020), pp.25-29, 5 p.
Publisher
University of Babylon College of Medicine
Publication Date
2020-03-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Bardoxolone inhibited proliferation and induced apoptosis in vitro in wide types of human cancer cells.
It has also been shown to inhibit the growth of tumor in the mice model.
Several studies demonstrated that bardoxolone may modulate multiple molecular targets that have a fundamental role in both the development and progression of cancer.
Objectives: The aim of this study is to assess the effects of Bardoxolone (CDDO-Me) in the treatment of colonic carcinoma by induction of the nuclear factor erythroid 2 relatedfactor 2-signaling pathway (Nrf2) with regression of tumor markers as compared to other chemotherapeutic agents like 5-fuorouracil.
Materials and Methods: Treatment groups are classified into four groups (control, chemotherapy group, bardoxolone, and combination treatment groups).
Results: The results revealed that there were significant effects of bardoxolone treatment on cytoplasmic Nrf2 level (P < 0.
05)as compared to control group (cancer cells without treatment).
Conclusion : Bardoxolone has significant anticancer effects (P < 0.
05) in low micrograms concentrations on human colonic cancer cells as compared to control groups.
American Psychological Association (APA)
al-Khafaji, Nail Abbas K.& al-Rikabi, Samir H.& Kammona, Talib H.& Ubayd, Hamid N.. 2020. Effects of bardoxolone on nuclear factor-erythroid 2-related factor 2 signaling pathway in HCT-116 human colonic cancer cell line : in vitro study. Medical Journal of Babylon،Vol. 17, no. 1, pp.25-29.
https://search.emarefa.net/detail/BIM-972627
Modern Language Association (MLA)
al-Khafaji, Nail Abbas K.…[et al.]. Effects of bardoxolone on nuclear factor-erythroid 2-related factor 2 signaling pathway in HCT-116 human colonic cancer cell line : in vitro study. Medical Journal of Babylon Vol. 17, no. 1 (Jan. / Mar. 2020), pp.25-29.
https://search.emarefa.net/detail/BIM-972627
American Medical Association (AMA)
al-Khafaji, Nail Abbas K.& al-Rikabi, Samir H.& Kammona, Talib H.& Ubayd, Hamid N.. Effects of bardoxolone on nuclear factor-erythroid 2-related factor 2 signaling pathway in HCT-116 human colonic cancer cell line : in vitro study. Medical Journal of Babylon. 2020. Vol. 17, no. 1, pp.25-29.
https://search.emarefa.net/detail/BIM-972627
Data Type
Journal Articles
Language
English
Notes
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Record ID
BIM-972627