Effects of bardoxolone on nuclear factor-erythroid 2-related factor 2 signaling pathway in HCT-116 human colonic cancer cell line : in vitro study

Joint Authors

al-Rikabi, Samir H.
Kammona, Talib H.
Ubayd, Hamid N.
al-Khafaji, Nail Abbas K.

Source

Medical Journal of Babylon

Issue

Vol. 17, Issue 1 (31 Mar. 2020), pp.25-29, 5 p.

Publisher

University of Babylon College of Medicine

Publication Date

2020-03-31

Country of Publication

Iraq

No. of Pages

5

Main Topic

Diseases
Medicine

Topics

Abstract EN

Background : Bardoxolone inhibited proliferation and induced apoptosis in vitro in wide types of human cancer cells.

It has also been shown to inhibit the growth of tumor in the mice model.

Several studies demonstrated that bardoxolone may modulate multiple molecular targets that have a fundamental role in both the development and progression of cancer.

Objectives: The aim of this study is to assess the effects of Bardoxolone (CDDO-Me) in the treatment of colonic carcinoma by induction of the nuclear factor erythroid 2 relatedfactor 2-signaling pathway (Nrf2) with regression of tumor markers as compared to other chemotherapeutic agents like 5-fuorouracil.

Materials and Methods: Treatment groups are classified into four groups (control, chemotherapy group, bardoxolone, and combination treatment groups).

Results: The results revealed that there were significant effects of bardoxolone treatment on cytoplasmic Nrf2 level (P < 0.

05)as compared to control group (cancer cells without treatment).

Conclusion : Bardoxolone has significant anticancer effects (P < 0.

05) in low micrograms concentrations on human colonic cancer cells as compared to control groups.

American Psychological Association (APA)

al-Khafaji, Nail Abbas K.& al-Rikabi, Samir H.& Kammona, Talib H.& Ubayd, Hamid N.. 2020. Effects of bardoxolone on nuclear factor-erythroid 2-related factor 2 signaling pathway in HCT-116 human colonic cancer cell line : in vitro study. Medical Journal of Babylon،Vol. 17, no. 1, pp.25-29.
https://search.emarefa.net/detail/BIM-972627

Modern Language Association (MLA)

al-Khafaji, Nail Abbas K.…[et al.]. Effects of bardoxolone on nuclear factor-erythroid 2-related factor 2 signaling pathway in HCT-116 human colonic cancer cell line : in vitro study. Medical Journal of Babylon Vol. 17, no. 1 (Jan. / Mar. 2020), pp.25-29.
https://search.emarefa.net/detail/BIM-972627

American Medical Association (AMA)

al-Khafaji, Nail Abbas K.& al-Rikabi, Samir H.& Kammona, Talib H.& Ubayd, Hamid N.. Effects of bardoxolone on nuclear factor-erythroid 2-related factor 2 signaling pathway in HCT-116 human colonic cancer cell line : in vitro study. Medical Journal of Babylon. 2020. Vol. 17, no. 1, pp.25-29.
https://search.emarefa.net/detail/BIM-972627

Data Type

Journal Articles

Language

English

Notes

-

Record ID

BIM-972627