Association of catechol-O-methyltransferase gene polymorphism with benign prostatic hyperplasia in Babylon Province

Joint Authors

Husayn, Nibras Yahya
al-Salman, Abd al-Razzaq
Awdah, Mufid J.

Source

Medical Journal of Babylon

Issue

Vol. 17, Issue 1 (31 Mar. 2020), pp.54-57, 4 p.

Publisher

University of Babylon College of Medicine

Publication Date

2020-03-31

Country of Publication

Iraq

No. of Pages

4

Main Topic

Diseases
Medicine

Topics

Abstract EN

Background : Benign prostatic hyperplasia (BPH) is a common nonmalignant disorder in elderly men.

Objectives : The objective of the present study was planned to evaluate the frequency and association of catechol-O-methyltransferase (COMT) gene G↔A (Val 158 Met)single-nucleotide polymorphism (SNP) with BPH in Babylon Province.

Materials and Methods : To accomplish this purpose, 146 patients with BPH and 102 apparently healthy controls were subjected to the study.

DNA was extracted from whole blood for all samples.

Genotyping of COMT gene G↔A (Val 158 Met) SNP was carried out by allele specific oligonucleotides polymerase chain reaction.

Results: Results indicated that the homozygous genotype (Met158Met) (AA) of COMT gene G↔A (Val 158 Met) SNP was found to be significantly increase the risk of BPH by three folds with respect to those of the wild genotype (Val158Val) (GG) of COMT gene G↔A (Val 158 Met) SNP.

The heterozygous genotype (Val158Met) (GA) of COMT gene G↔A (Val 158 Met) SNP was found to be none significantly increase the risk of BPH with respect to those of the wild genotype (Val158Val) (GG) of COMT gene G↔A (Val 158 Met) SNP.

The minor allele frequencies (A) of COMT gene G↔A (Val 158 Met) SNP were significantly higher in BPH patients when compared with that of the control group.

Conclusions: The COMT gene G↔A (Val 158 Met) SNP is involved in the pathogenesis of BPH

American Psychological Association (APA)

Husayn, Nibras Yahya& Awdah, Mufid J.& al-Salman, Abd al-Razzaq. 2020. Association of catechol-O-methyltransferase gene polymorphism with benign prostatic hyperplasia in Babylon Province. Medical Journal of Babylon،Vol. 17, no. 1, pp.54-57.
https://search.emarefa.net/detail/BIM-972632

Modern Language Association (MLA)

al-Salman, Abd al-Razzaq…[et al.]. Association of catechol-O-methyltransferase gene polymorphism with benign prostatic hyperplasia in Babylon Province. Medical Journal of Babylon Vol. 17, no. 1 (Jan. / Mar. 2020), pp.54-57.
https://search.emarefa.net/detail/BIM-972632

American Medical Association (AMA)

Husayn, Nibras Yahya& Awdah, Mufid J.& al-Salman, Abd al-Razzaq. Association of catechol-O-methyltransferase gene polymorphism with benign prostatic hyperplasia in Babylon Province. Medical Journal of Babylon. 2020. Vol. 17, no. 1, pp.54-57.
https://search.emarefa.net/detail/BIM-972632

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 57

Record ID

BIM-972632