Co-amorphous system : a promising strategy for delivering poorly water-soluble drugs

Abstract EN

Amorphization of drug has been considered as an attractive approach in improving drug solubility and bioavailability.

Unlike their crystalline counterparts, amorphous materials lack the long-range order of molecular packing and present the highest energy state of a solid material.

Co-amorphous system (CAM) is a multi-component single phase system containing an active pharmaceutical ingredient (API) with a low molecular weight excipient or a pharmacologically relevant API.

This review highlights the different approaches followed in the preparation of co-amorphous drug delivery system, and the proper selection of the co-formers.

In addition, the recent advances in solid state characterization, industrial scale and formulation will be discussed.