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Enhancement of aqueous solubility and dissolution rate of etoricoxib by solid dispersion technique
Other Title(s)
تعزيز قابلية الذوبان و معدل الانحلال للاتوريكوكسيب بتقنية المنتشر الصلب
Parallel Title
تعزيز قابلية الذوبان و معدل الانحلال للاتوريكوكسيب بتقنية المنتشر الصلب
Joint Authors
Abd al-Rahman, Mustafa Muzaffar
Jawad, Fatimah J.
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 29, Issue 1 (30 Jun. 2020), pp.76-87, 12 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2020-06-30
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
Abstract EN
Etoricoxib (EXB) is a highly selective cox-2 inhibitor which belongs to the non-steroidal anti-inflammatory drug (NSAID).
EXB is a class II drug according to the biopharmaceutical classification system (BCS), which possess a very low aqueous solubility in water.
In the present study, many trials were made to improve the aqueous solubility and dissolution rate of EXB by solid dispersion technique.
Eighteenth EXB formulas were formulated as a solid dispersion using a variety of hydrophilic polymers (as carriers) including poloxamer 407 (PXM 407), poloxamer 188 (PXM 188) and polyethylene glycol 4000 (PEG 4000) at different drug: polymer ratios (1: 1, 1: 3 and 1: 5).
These formulas were prepared by two methods; solvent evaporation and fusion method.
The prepared formulas were evaluated for practical yield percent (PY %), drug content, saturated solubility and release rate, Fourier transforms infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder x-ray diffraction (PXRD).
It was found that the solubility was affected by the polymer type and the method of preparation.
The polymers (as carriers) used to prepare EXB- solid dispersion showed improvement in the solubility in the following descending order; PXM 407>PXM 188> PEG 4000.
The optimum formula (SD15) composed of the drug: PXM 407 at a ratio of 1: 5 was prepared by solvent evaporation showed 7.
76 folds (676.
40%) solubility improvement as compared to pure EXB.
The optimum formula showed a release rate of 99.
8% through the first 15 min.
The advance characterization of the selected formula indicated the possible transformation of the drug to the amorphous state.
American Psychological Association (APA)
Abd al-Rahman, Mustafa Muzaffar& Jawad, Fatimah J.. 2020. Enhancement of aqueous solubility and dissolution rate of etoricoxib by solid dispersion technique. Iraqi Journal of Pharmaceutical Sciences،Vol. 29, no. 1, pp.76-87.
https://search.emarefa.net/detail/BIM-972710
Modern Language Association (MLA)
Abd al-Rahman, Mustafa Muzaffar& Jawad, Fatimah J.. Enhancement of aqueous solubility and dissolution rate of etoricoxib by solid dispersion technique. Iraqi Journal of Pharmaceutical Sciences Vol. 29, no. 1 (2020), pp.76-87.
https://search.emarefa.net/detail/BIM-972710
American Medical Association (AMA)
Abd al-Rahman, Mustafa Muzaffar& Jawad, Fatimah J.. Enhancement of aqueous solubility and dissolution rate of etoricoxib by solid dispersion technique. Iraqi Journal of Pharmaceutical Sciences. 2020. Vol. 29, no. 1, pp.76-87.
https://search.emarefa.net/detail/BIM-972710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 86-87
Record ID
BIM-972710