Effect of quercetin on the biochemical parameters of the alloxan induced diabetes in male rats

Abstract EN

Oxidative stress constructions is directly concerned with diabetes mellitus.

For that reason, this study was performed to look into the biochemical variation occurred by oxidative anxiety and to estimate the antioxidant effect of quercetin in alloxan formed diabetes in male albino rats.

The rats were thirty six male albino rats, they were divided into six groups 6 rats per each were treated as follows: control group, quercetin group (50mg/kg), Diabetic control group, Diabetic with quercetin group, Diabetic with insulin group, Diabetic with quercetin plus insulin group.

The result illustrated that diabetes caused a significant increased in glucose, alanine aminotransferase, alkaline Phosphatase, aspartate aminotransferase, triglycerides, cholesterol, urea and creatinine level in serum of rats.

Whereas the albumin level was decreased considerably.

In opposition, quercetin significantly changed the level of biochemical enzymes and oxidative markers used in this study with or without insulin.

It has been concluded that the quercetin could be shown as a potential antioxidants in reducing the risk of oxidation induced by diabetes that lead to damage of the pancreas, liver and kidney.