Evaluation of serum hepatitis B surface antigen quantification kinetics in different patterns of chronic hepatitis B infection
Joint Authors
Makki, Muhammad A.
Mahran, Zaynab G.
Riyad, Ayah A. S.
Abu al-Fath, Ahmad M.
Suwayfi, Yusuf M.
Source
Journal of Current Medical Research and Practice
Issue
Vol. 5, Issue 2 (30 Jun. 2020), pp.141-145, 5 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2020-06-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and aim Management of chronic hepatitis B (CHB) infection is challenging owing to its wide immunologic phases and pathologic patterns.
Quantification of serum HBs‑Ag (qHBsAg) has been used as a mirror of intrahepatic viral replication, and therefore, its kinetics in these patterns may reflect diseases severity and hence may help in tailoring the management plan.
So, this study was designed to assess the patterns and kinetics of qHBsAg among Egyptian patients presented with different forms of CHB.
Patients and methods Between December 2016 and December 2017, patients with CHB were enrolled and categorized into three groups.
Group I included naive aviremic patients [those with negative hepatitis B virus (HBV)-DNA-PCR without treatment].
Group II included naive low viremic patients (those with HBV-DNA-PCR <2000 IU/ml without treatment).
Group III included treatment-experienced aviremic patients (those with negative HBV-DNA-PCR after 6 months of nucleotide analog treatment).
All patients were checked for alanine aminotransferase (ALT), qHBsAg, and HBV‑DNA‑PCR at a regular intervals: at baseline (W0), week 12 (W12), and week 24 (w24).
Results A total of 90 patients were enrolled, with 30 patients in each group.
In group I, qHBsAg and ALT levels exhibited relatively stable detectable positively correlated levels from W0 to W24.
In group II, qHBsAg and ALT levels were the same as group I.
In group III, qHBsAg, ALT levels, and HBV‑DNA exhibited a significant decrease during the follow‑up with the use of nucleotide analog therapy.
Conclusion qHBsAg measurement, which is a cheap and easy test, can replace HBV-DNA and may help in reflection of disease activity and assessment of follow‑up
American Psychological Association (APA)
Makki, Muhammad A.& Mahran, Zaynab G.& Riyad, Ayah A. S.& Abu al-Fath, Ahmad M.& Suwayfi, Yusuf M.. 2020. Evaluation of serum hepatitis B surface antigen quantification kinetics in different patterns of chronic hepatitis B infection. Journal of Current Medical Research and Practice،Vol. 5, no. 2, pp.141-145.
https://search.emarefa.net/detail/BIM-975087
Modern Language Association (MLA)
Makki, Muhammad A.…[et al.]. Evaluation of serum hepatitis B surface antigen quantification kinetics in different patterns of chronic hepatitis B infection. Journal of Current Medical Research and Practice Vol. 5, no. 2 (Apr. / Jun. 2020), pp.141-145.
https://search.emarefa.net/detail/BIM-975087
American Medical Association (AMA)
Makki, Muhammad A.& Mahran, Zaynab G.& Riyad, Ayah A. S.& Abu al-Fath, Ahmad M.& Suwayfi, Yusuf M.. Evaluation of serum hepatitis B surface antigen quantification kinetics in different patterns of chronic hepatitis B infection. Journal of Current Medical Research and Practice. 2020. Vol. 5, no. 2, pp.141-145.
https://search.emarefa.net/detail/BIM-975087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 145
Record ID
BIM-975087