![](/images/graphics-bg.png)
Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-Irradiation
Joint Authors
al-Sanbati, Sawsan Muhammad
Abd al-Fattah, Habibah Abd al-Wahhab
al-Qabbani, Hanan Ahmad
Izz, Majidah Kamal
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 53, Issue 1 (31 Jan. 2020), pp.172-181, 10 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2020-01-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is considered a systemic inflammatory disease that affects not only the joints but also other organs in the body causing many extra-articular complications.
Low-dose radiation (LDR) modulates a variety of immune responses that have exhibited the properties of immune hormesis.
LDR has been used clinically for the treatment of autoimmune diseases.
Several molecular mechanisms and cellular components contribute to the clinical efficacy of low dose radiotherapy (LD-RT).
The present study aimed to evaluate the possible capability of low dose γ-irradiation to reduce some of these extra-articular complications in adjuvant-induced arthritis model in rats.
Our results revealed a significant increase in liver parameters in serum including ALT, AST activities as well as creatinine level in adjuvant induced arthritic rats that indicate liver and kidney impairment respectively.
Results also revealed sharp increase in total leukocytic count (TLC).
All of these biochemical and hematological disturbances were found to be significantly improved after exposure to low dose γ-irradiation.
American Psychological Association (APA)
Abd al-Fattah, Habibah Abd al-Wahhab& Izz, Majidah Kamal& al-Qabbani, Hanan Ahmad& al-Sanbati, Sawsan Muhammad. 2020. Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-Irradiation. Arab Journal of Nuclear Sciences and Applications،Vol. 53, no. 1, pp.172-181.
https://search.emarefa.net/detail/BIM-975118
Modern Language Association (MLA)
Abd al-Fattah, Habibah Abd al-Wahhab…[et al.]. Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-Irradiation. Arab Journal of Nuclear Sciences and Applications Vol. 53, no. 1 (2020), pp.172-181.
https://search.emarefa.net/detail/BIM-975118
American Medical Association (AMA)
Abd al-Fattah, Habibah Abd al-Wahhab& Izz, Majidah Kamal& al-Qabbani, Hanan Ahmad& al-Sanbati, Sawsan Muhammad. Reduction of some extra-articular complications associated with arthritis development in rats by low dose γ-Irradiation. Arab Journal of Nuclear Sciences and Applications. 2020. Vol. 53, no. 1, pp.172-181.
https://search.emarefa.net/detail/BIM-975118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 178-181
Record ID
BIM-975118