Anticancer activity of fermented solenostemm aargel extract and-or low dose gamma radiation against hepatocellular carcinoma
Joint Authors
al-Sanbati, Sawsan Muhammad
Hassan, Asma A.
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 53, Issue 1 (31 Jan. 2020), pp.234-242, 9 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2020-01-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
For many decades the terrestrial plants are represent an infinitive source of bioactive substances as well as pharmaceutical components which play a main role in the discovering ,developing and manufacturing of anticancer and antibiotic drugs.Solenostemmaargel is a desert plant widely used in Arabic countries as antispasmodic, anti-inflammatory and anti-rheumatic agent.
It also has anti-tumor activity.
Aim: the present study was oriented to investigatethe hepato-protective effect of fermentedSolenostemmaargelleave extract (100amg/kg b.wt) and/or low dose γ-radiation (0.5Gy) againsthepatocellular carcinoma (HCC)developedin rats by injection of diethylnitrosamine.
Results: the data obtained revealed that thepro-apoptotic agents (caspase 3 and cytochrome c) undergoes significant elevation in HCC rats received plant extract and/or γ-radiation compared to HCC rats.While,the vascular endothelial growth factor (VEGF), hypoxia inducible factor-α (HIF-α)and monocytichemotactic protein-1(MCP-1) were significantly decreased.
Also, the activity of cyclooxygenase-2 (COX-2) was significantly decreased.
Moreover, the histopathological analysis revealed that a mild improvement .In conclusion, the improvement emerged in HCC rats could be attributed to the potency of extract and/or γ- radiation by induce apoptosis and reduce angiogenesis.
American Psychological Association (APA)
al-Sanbati, Sawsan Muhammad& Hassan, Asma A.. 2020. Anticancer activity of fermented solenostemm aargel extract and-or low dose gamma radiation against hepatocellular carcinoma. Arab Journal of Nuclear Sciences and Applications،Vol. 53, no. 1, pp.234-242.
https://search.emarefa.net/detail/BIM-975124
Modern Language Association (MLA)
al-Sanbati, Sawsan Muhammad& Hassan, Asma A.. Anticancer activity of fermented solenostemm aargel extract and-or low dose gamma radiation against hepatocellular carcinoma. Arab Journal of Nuclear Sciences and Applications Vol. 53, no. 1 (2020), pp.234-242.
https://search.emarefa.net/detail/BIM-975124
American Medical Association (AMA)
al-Sanbati, Sawsan Muhammad& Hassan, Asma A.. Anticancer activity of fermented solenostemm aargel extract and-or low dose gamma radiation against hepatocellular carcinoma. Arab Journal of Nuclear Sciences and Applications. 2020. Vol. 53, no. 1, pp.234-242.
https://search.emarefa.net/detail/BIM-975124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 240-242
Record ID
BIM-975124