Effect of oily vehicles on the bioavailability of orally administered, sodium saliclates in rabbit

Abstract EN

The bioavailability of sodium salicylate administered in aqueous, glycerin and oily vehicles was compared in rabbits.

Glycerin formulation was compared with both aqueous and oily formulations using a two-way crossover test in eight rabbits, in each study.

The results indicate that the oily formulation gave a lower rate of absorption and a greater extent of absorption than the other formulations.

No significant difference in the rate and extent of absorption was shown between glycerin and aqueous formulations.

Possible reasons for the differences are discussed with particular reference to the effects of oils on the gastric emptying rate.