The effect of the intravenous dexmedetomidine on the duration of sensory and motor blockade after subarachnoid block

Abstract EN

Background : Spinal block, a known technique to obtain anaesthesia for infra umbilical surgeries.

Now physician have advantage of using adjuvant to prolong the effect of intrathecal block, which can be given either intravenously or intrathecally, dexmedetomidine is one of them.

We studied effect of intravenous dexmedetomidine for prolongation of duration of intrathecal block of 0.5% bupivacaine block.

Aim: To evaluate the effect of intravenous dexmedetomidine on sensory and motor blockade duration after subarachnoid block (SAB) with bupivacaine 0.5 % .

Methods: a prospective, randomized, double blind, placebo controlled study was carried out in general surgical operation theaters of Baghdad teaching hospital, during the period from 1st March to 30th April 2016Fifty patients of ASA grade I, II are posted for elective infraumblical surgeries were included in the study and randomly allocated into two groups.

Group D contain 25 patients received intrathecal 0.5% hyperbaric bupivacaine, followed after 10 minutes by infusion of intravenous dexmedetomidine 1mic/kg in 100 ml normal saline over 10 min.

Group (C) contain 25 patients received intrathecal 0.5% hyperbaric bupivacaine 3ml followed after 10 minutes by infusion of same volume of normal saline as placebo.

-Person's chi-squre was used to assess statistical association between categorical data.

-Analysis of variance(ANOVA) was used to assess the difference between the continuous variables.

level of p-value less than 0.05 was significant.

Result: .

Duration of analgesia in group D was 202.28 + _ 4.46 and in group C was 159.6 + _3.12 min.

highly significant (p < 0.0001).

Duration of motor blockage in group D was 154.44+_ 7.06 minutes and in group C was 131.04 min.

highly significant (P = < 0.0001) Conclusion : Administration of intravenous dexmedetomidine 10 min.

after SAB (infusion of 1mcg / kg over 10 min.) prolongs the duration of sensory and motor block.