The effect of monosodium glutamate alone or with lycopene on some physiological and biochemical parameters in adult male rats

Abstract EN

In the current investigation, the antioxidant action of lycopene was examined experimentally through deference en route for its protecting properties in contrast to the effect of monosodium glutamate which prompted oxidative stress happening in rats.

Sixty of male rats divided randomly in to six groups (ten in each) were use in my study.

G1 represented control, in which administered normal saline.

G2 was given MSG (20 mg/kg) for 30 days, by orally administration.

The third group received MSG (20 mg/kg, 15days) also orally administration followed with treatment by lycopene (200mg/kg) for another 15 days.

G4 administrated in cooperation lycopene (200 mg/kg) for 15 days, also by orally administration followed treatment by MSG(20mg/kg)for another fifteen days.

Rats in the fifth group received MSG (20 mg/kg) and lycopene(100mg/kg) also orally administration for thirty days.

While the six group the rats received MSG (20 mg/kg ) and lycopene (200 mg/kg) also orally administration for thirty days.

The animals were mastered the body weight then euthanized after 30 days.

The whole blood was collecting in order to determine the hematological levels as well as some of the serum hormone as well as ACTH, Cortisol, TSH, T3 and T4.

The data showed that the body weight gain reduce in G4 and G5, while, RBCs parameters most of them showed increase in all co-treated groups, the result of ACTH all treated groups showed a significant increase (p<0.05) as compared with the control, cortisol level in all treated group had a significant decrease (p<0.05) as compared with the control.

While, TSH level had not any significant differences.

But, the result of T3 level had showed a significant decrease(p<0.05) as compared with the control, while, T4 level was an increase only in MSG group.

We found that treatment with lycopene reduced some of the harmful effects of MSG in rats and oxidative stress.