Effect of monosodium glutamate (MSG)‎ on tissue and function of liver and kidney and body weight in male albino Mice

Other Title(s)

تأثير غلوتامات أحادية الصوديوم على نسيج و وظائف الكبد و الكلى ووزن الجسم في ذكور الفئران البيضاء

Author

Muslim, Zahra Zuhayr

Source

Journal of College of Education for Pure Sciences

Issue

Vol. 10, Issue 1 (30 Sep. 2020), pp.1-12, 12 p.

Publisher

University of Thi-Qar College of Education for Pure Sciences

Publication Date

2020-09-30

Country of Publication

Iraq

No. of Pages

12

Main Topic

Biology
Veterinary Medicine

Topics

Abstract AR

مادة الغلوتامات أحادية الصوديوم عادة تستخدم كمواد مضافة الى الاطعمة محسنة للنكهة، الهدف من هذه الدراسة معرفة تأثير مادة الغلوتامات أحادية الصوديوم على الكبد و الكلية ذكور الفئران البالغة حيث استخدم في هذه التجربة (20) فار (10) حيوانات استخدمت كمجموعة سيطرة و (10) اخرى جرعت (100) ملغم كغم من وزن الجسم حيث بينت النتائج زيادة معنوية في وزن الجسم و الكبد و الكلية في الفئران المعاملة بمادة الغلوتامات أحادية الصوديوم كما بينت الدراسة زيادة في انزيمات الكبد و اليوريا و الكرياتينين أما الفحص النسيجي لأنسجة الكبد اظهرت التهاب خفيف في منطقة البوابة، نخر في خلايا الكبد، اعتلال في بناء لحمة الكبد، احتقان الوريد الكبدي و توسع الوريد الكبدي المركزي، في حين أن الفحص النسيجي لأنسجة الكلى يظهر تحلل خزبي من الخلايا الأنبوبية و تنكس زجاجي في نبيبات الكلى، ووجود الخلايا الالتهابية في نسيج الكبد و التصلب الجزئي للكبيبات.

Abstract EN

Monosodium glutamate is wider used for additive and as a flavor enhancer.

This study aimed to evaluate the effect of MSG on liver and kidneys of albino mice by measuring of biochemical parameter (ALT, AST, Urea and Creatinine), (body, liver and kidney) weight were measured in this study and histological examination of liver and kidneys tissues, twenty albino mice were used in this present which randomly divided in to two group, the experimental group (10 mice) received MSG 100 mg / kg daily for 30 days, the results showed significance increase in the body weight in MSG treated group compared to the control group, MSG cause increases in liver and kidney weight in treated group compared to the control group.

The results also showed significant increase in ALT and AST in treated group compared to the control group, also the urea and creatinine increased in experimental group compared to control group.

The histological examination off liver tissues showed mild inflammation of portal area, necrosis in the hepatocytes, abnormal hepatic parenchyma architecture, congested hepatic vein and dilated central hepatic vein, while the, histological examination of kidney tissues shows hydropic degeneration of tubular cells of the kidney dilated tubules of kidney hyalinization and hyaline cast of renal tubules, interstitial mononuclear” inflammatory cells and partial sclerosis of glomerulus.

American Psychological Association (APA)

Muslim, Zahra Zuhayr. 2020. Effect of monosodium glutamate (MSG) on tissue and function of liver and kidney and body weight in male albino Mice. Journal of College of Education for Pure Sciences،Vol. 10, no. 1, pp.1-12.
https://search.emarefa.net/detail/BIM-978933

Modern Language Association (MLA)

Muslim, Zahra Zuhayr. Effect of monosodium glutamate (MSG) on tissue and function of liver and kidney and body weight in male albino Mice. Journal of College of Education for Pure Sciences Vol. 10, no. 1 (Sep. 2020), pp.1-12.
https://search.emarefa.net/detail/BIM-978933

American Medical Association (AMA)

Muslim, Zahra Zuhayr. Effect of monosodium glutamate (MSG) on tissue and function of liver and kidney and body weight in male albino Mice. Journal of College of Education for Pure Sciences. 2020. Vol. 10, no. 1, pp.1-12.
https://search.emarefa.net/detail/BIM-978933

Data Type

Journal Articles

Language

English

Notes

تم أخذ الملخص باللغة العربية من موقع المجلة.

Record ID

BIM-978933