Effect of monosodium glutamate (MSG)‎ on tissue and function of liver and kidney and body weight in male albino Mice

Abstract EN

Monosodium glutamate is wider used for additive and as a flavor enhancer.

This study aimed to evaluate the effect of MSG on liver and kidneys of albino mice by measuring of biochemical parameter (ALT, AST, Urea and Creatinine), (body, liver and kidney) weight were measured in this study and histological examination of liver and kidneys tissues, twenty albino mice were used in this present which randomly divided in to two group, the experimental group (10 mice) received MSG 100 mg / kg daily for 30 days, the results showed significance increase in the body weight in MSG treated group compared to the control group, MSG cause increases in liver and kidney weight in treated group compared to the control group.

The results also showed significant increase in ALT and AST in treated group compared to the control group, also the urea and creatinine increased in experimental group compared to control group.

The histological examination off liver tissues showed mild inflammation of portal area, necrosis in the hepatocytes, abnormal hepatic parenchyma architecture, congested hepatic vein and dilated central hepatic vein, while the, histological examination of kidney tissues shows hydropic degeneration of tubular cells of the kidney dilated tubules of kidney hyalinization and hyaline cast of renal tubules, interstitial mononuclear” inflammatory cells and partial sclerosis of glomerulus.