Taraxacum officinale (Dandelion)‎ roots extract mitigates doxorubicin-induced hematocardiotoxicity in male albino rats

Author

Jad al-Karim, Dina R. S.

Source

Journal of Veterinary Medical Research

Issue

Vol. 26, Issue 2 (31 Dec. 2019), pp.235-246, 12 p.

Publisher

Beni-Suef University Faculty of Veterinary Medicine

Publication Date

2019-12-31

Country of Publication

Egypt

No. of Pages

12

Main Topic

Biology
Veterinary Medicine

Topics

Abstract EN

The present study was designed to evaluate the probable ameliorative effect of dandelion extract against doxorubicin hemato-cardiotoxicity.

To accomplish this study, four groups of male albino rats (n = 7) were used as follow, Group I : served as a control group, Group II : received dandelion extract (200 mg / kg), Group III : received doxorubicin (2.5 mg / kg) and Group IV : received dandelion extract and doxorubicin identically to groups II and III.

Doxorubicin was administrated 3times / week for two consecutive weeks, while dandelion extract was administrated daily for two consecutive weeks before doxorubicin administration and continued during doxorubicin treatment.

The results illuminated that, administration of doxorubicin has a deleterious effect on both of blood cellular components and cardiac tissues, which was indicated by significant pancytopenia (decrease in all blood cell types), elevated serum cardiac enzymes activity (CK-MB and LDH), increased serum level of cardiacrelated proteins (troponin I, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) with a depletion of cardiac tissues antioxidant (GSH, and SOD enzyme) and elevated lipid peroxide (MDA) level in this tissues.

Co-administration of dandelion extract with doxorubicin significantly alleviated its hemato-cardiotoxic effect which was reflected positively on hemato-biochemical changes and cardiac histopathological alterations.

American Psychological Association (APA)

Jad al-Karim, Dina R. S.. 2019. Taraxacum officinale (Dandelion) roots extract mitigates doxorubicin-induced hematocardiotoxicity in male albino rats. Journal of Veterinary Medical Research،Vol. 26, no. 2, pp.235-246.
https://search.emarefa.net/detail/BIM-979225

Modern Language Association (MLA)

Jad al-Karim, Dina R. S.. Taraxacum officinale (Dandelion) roots extract mitigates doxorubicin-induced hematocardiotoxicity in male albino rats. Journal of Veterinary Medical Research Vol. 26, no. 2 (2019), pp.235-246.
https://search.emarefa.net/detail/BIM-979225

American Medical Association (AMA)

Jad al-Karim, Dina R. S.. Taraxacum officinale (Dandelion) roots extract mitigates doxorubicin-induced hematocardiotoxicity in male albino rats. Journal of Veterinary Medical Research. 2019. Vol. 26, no. 2, pp.235-246.
https://search.emarefa.net/detail/BIM-979225

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 243-246

Record ID

BIM-979225