Taraxacum officinale (Dandelion) roots extract mitigates doxorubicin-induced hematocardiotoxicity in male albino rats
Author
Source
Journal of Veterinary Medical Research
Issue
Vol. 26, Issue 2 (31 Dec. 2019), pp.235-246, 12 p.
Publisher
Beni-Suef University Faculty of Veterinary Medicine
Publication Date
2019-12-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
The present study was designed to evaluate the probable ameliorative effect of dandelion extract against doxorubicin hemato-cardiotoxicity.
To accomplish this study, four groups of male albino rats (n = 7) were used as follow, Group I : served as a control group, Group II : received dandelion extract (200 mg / kg), Group III : received doxorubicin (2.5 mg / kg) and Group IV : received dandelion extract and doxorubicin identically to groups II and III.
Doxorubicin was administrated 3times / week for two consecutive weeks, while dandelion extract was administrated daily for two consecutive weeks before doxorubicin administration and continued during doxorubicin treatment.
The results illuminated that, administration of doxorubicin has a deleterious effect on both of blood cellular components and cardiac tissues, which was indicated by significant pancytopenia (decrease in all blood cell types), elevated serum cardiac enzymes activity (CK-MB and LDH), increased serum level of cardiacrelated proteins (troponin I, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) with a depletion of cardiac tissues antioxidant (GSH, and SOD enzyme) and elevated lipid peroxide (MDA) level in this tissues.
Co-administration of dandelion extract with doxorubicin significantly alleviated its hemato-cardiotoxic effect which was reflected positively on hemato-biochemical changes and cardiac histopathological alterations.
American Psychological Association (APA)
Jad al-Karim, Dina R. S.. 2019. Taraxacum officinale (Dandelion) roots extract mitigates doxorubicin-induced hematocardiotoxicity in male albino rats. Journal of Veterinary Medical Research،Vol. 26, no. 2, pp.235-246.
https://search.emarefa.net/detail/BIM-979225
Modern Language Association (MLA)
Jad al-Karim, Dina R. S.. Taraxacum officinale (Dandelion) roots extract mitigates doxorubicin-induced hematocardiotoxicity in male albino rats. Journal of Veterinary Medical Research Vol. 26, no. 2 (2019), pp.235-246.
https://search.emarefa.net/detail/BIM-979225
American Medical Association (AMA)
Jad al-Karim, Dina R. S.. Taraxacum officinale (Dandelion) roots extract mitigates doxorubicin-induced hematocardiotoxicity in male albino rats. Journal of Veterinary Medical Research. 2019. Vol. 26, no. 2, pp.235-246.
https://search.emarefa.net/detail/BIM-979225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 243-246
Record ID
BIM-979225