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Immunologic Response of HIV-Infected Children to Different Regimens of Antiretroviral Therapy: A Retrospective Observational Study
Joint Authors
Mega, Teshale Ayele
Usamo, Firehiwot Belayneh
Negera, Getandale Zeleke
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Both abacavir- (ABC-) based and zidovudine- (AZT-) based regimens are widely utilized for managing HIV infection in children.
Unfortunately, there is a lack of data regarding their immunological response and associated risk factors in Ethiopia.
Methods.
A retrospective hospital-based cohort study was conducted on HIV-infected children in Jimma Medical Center (JMC).
A total of 179 records were reviewed by including data from November 2015 to April 2017.
Data were collected on sociodemographic, clinical characteristics of patients and drug-related variables.
Data analysis was done using STATA 13.1.
Mixed-effect linear regression was performed to assess the difference in CD4+ changes between groups adjusting for baseline characteristics.
The change in predicted CD4 count attributed to each regimen was also assessed by marginal analysis.
P<0.05 for slope of the random-effect linear regression was used as an indicator for the presence of association.
Result.
Of 179 patients, 98 (54.7%) were females.
The mean (±SD) duration of follow-up was 939.8 ± 478.3 and 984.92 ± 453.1 days for ABC and AZT groups, respectively.
AZT group had a significant CD4+ count gain per visit compared with their ABC counterparts ((β = 20.51, 95% CI [6.37–34.65]), P=0.004) over time.
The regimen AZT + 3TC + LPV/r tended to have an excellent predicted CD4+ lymphocyte count change relative to all other regimens, while ABC + 3TC + LPV/r had the least immunologic recovery (margins 338.0 cells/mm3 versus 249.13 cells/mm3 (P<0.001)).
Baseline CD4+ lymphocyte count, ART group, WHO clinical stages, and viral load were independent predictors for CD4+ change overtime.
Conclusion.
AZT-based regimens seem to have better immunological response compared to ABC-based regimens.
Immunologic response was described worse in patients with a viral load of >1000copies/ml, low baseline CD4+ count, advanced WHO clinical stages, and ABC-containing regimens.
Further study is needed to clarify these aspects.
American Psychological Association (APA)
Mega, Teshale Ayele& Usamo, Firehiwot Belayneh& Negera, Getandale Zeleke. 2020. Immunologic Response of HIV-Infected Children to Different Regimens of Antiretroviral Therapy: A Retrospective Observational Study. AIDS Research and Treatment،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-986231
Modern Language Association (MLA)
Mega, Teshale Ayele…[et al.]. Immunologic Response of HIV-Infected Children to Different Regimens of Antiretroviral Therapy: A Retrospective Observational Study. AIDS Research and Treatment No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-986231
American Medical Association (AMA)
Mega, Teshale Ayele& Usamo, Firehiwot Belayneh& Negera, Getandale Zeleke. Immunologic Response of HIV-Infected Children to Different Regimens of Antiretroviral Therapy: A Retrospective Observational Study. AIDS Research and Treatment. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-986231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-986231