Overweight and Obesity among Recipients of Antiretroviral Therapy at HIV Clinics in Gaborone, Botswana: Factors Associated with Change in Body Mass Index
Joint Authors
Tshikuka, Jose Gaby
Magafu, Mgaywa Gilbert Mjungu Damas
Rankgoane-Pono, Goabaone
Mwita, Julius Chacha
Masupe, Tiny
Hamda, Shimeles Genna
Tapera, Roy
Molefi, Mooketsi
Tshibangu, Joseph
Tlhakanelo, John Thato
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Factors associated with overweight/obesity among antiretroviral therapy (ART) recipients have not been sufficiently studied in Botswana.
Objectives.
To: (i) estimate the prevalence and trends in overweight/obesity by duration of exposure to ART among recipients, (ii) assess changes in BMI categories among ART recipients between their first clinic visit (BMI-1) and their last clinic visit (BMI-2), (iii) identify ART regimen that predicts overweight/obesity better than the others and factors associated with BMI changes among ART recipients.
Methods.
A 12-year retrospective record-based review was conducted.
Potential predictors of BMI change among patients after at least three years of ART exposure were examined using a multiple logistic regression model.
Adjusted odds ratios (AOR) and their 95% confidence intervals (CIs) were computed.
ART regimens, duration of exposure to ART, and recipients’ demographic and biomedical characteristics including the presence or absence of diabetes mellitus-related comorbidities (DRC), defined as any morbidity associated with type 2 diabetes as described in the international statistical classification of diseases and related health problems (ICD-10-CM) codebook index, were investigated as potential predictors of overweight/obesity.
Results.
Twenty-nine percent of recipients were overweight, 16.6% had obesity of whom 2.4% were morbidly-obese at the last clinic visit.
Overweight/obese recipients were more likely to be female, to have DRC and less likely to have CD4 count between 201 and 249 cells/mm3.
Neither the first-line nor the second-, third-line ART regimens predicted overweight/obesity better than the other and neither did the duration of exposure to ART.
No significant linear trends were observed in the prevalence of overweight/obesity by the duration of exposure to ART.
Conclusion.
These results suggest that the ART regimens studied have a comparable effect on overweight/obesity and that the duration of exposure does not affect the outcome.
This study calls for further research to elucidate the relative contribution of various factors to BMI change among recipients, including ART regimens.
American Psychological Association (APA)
Tshikuka, Jose Gaby& Magafu, Mgaywa Gilbert Mjungu Damas& Rankgoane-Pono, Goabaone& Mwita, Julius Chacha& Masupe, Tiny& Hamda, Shimeles Genna…[et al.]. 2020. Overweight and Obesity among Recipients of Antiretroviral Therapy at HIV Clinics in Gaborone, Botswana: Factors Associated with Change in Body Mass Index. AIDS Research and Treatment،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-986237
Modern Language Association (MLA)
Tshikuka, Jose Gaby…[et al.]. Overweight and Obesity among Recipients of Antiretroviral Therapy at HIV Clinics in Gaborone, Botswana: Factors Associated with Change in Body Mass Index. AIDS Research and Treatment No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-986237
American Medical Association (AMA)
Tshikuka, Jose Gaby& Magafu, Mgaywa Gilbert Mjungu Damas& Rankgoane-Pono, Goabaone& Mwita, Julius Chacha& Masupe, Tiny& Hamda, Shimeles Genna…[et al.]. Overweight and Obesity among Recipients of Antiretroviral Therapy at HIV Clinics in Gaborone, Botswana: Factors Associated with Change in Body Mass Index. AIDS Research and Treatment. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-986237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-986237