Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity
Joint Authors
Elsharif, Asma M.
Youssef, Tamer E.
Al-Jameel, Suhailah S.
Mohamed, Hanan H.
Ansari, Mohammad Azam
Rehman, Suriya
Akhtar, Sultan
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study was to synthesize a series of nickel(II)phthalocyanines (NiPcs) bearing four 4(3H)-quinazolinone ring system units, (qz)4NiPcs 4a–d.
The electronic factors in the 4(3H)-quinazolinone moiety that attached to the NiPc skeleton had a magnificent effect on the antibacterial activity of the newly synthesized (qz)4NiPcs 4a–d against Escherichia coli.
The minimum MICs and MBCs value were recorded for compounds 4a, 4b, 4c, and 4d, respectively.
The results indicated that the studied (qz)4NiPcs 4a–d units possessed a broad spectrum of activity against Escherichia coli.
Their antibacterial activities were found in the order of 4d > 4c > 4b > 4a against Escherichia coli, and the strongest antibacterial activity was achieved with compound 4d.
American Psychological Association (APA)
Elsharif, Asma M.& Youssef, Tamer E.& Al-Jameel, Suhailah S.& Mohamed, Hanan H.& Ansari, Mohammad Azam& Rehman, Suriya…[et al.]. 2019. Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-986298
Modern Language Association (MLA)
Elsharif, Asma M.…[et al.]. Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity. Advances in Pharmacological and Pharmaceutical Sciences No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-986298
American Medical Association (AMA)
Elsharif, Asma M.& Youssef, Tamer E.& Al-Jameel, Suhailah S.& Mohamed, Hanan H.& Ansari, Mohammad Azam& Rehman, Suriya…[et al.]. Synthesis of an Activatable Tetra-Substituted Nickel Phthalocyanines-4(3H)-quinazolinone Conjugate and Its Antibacterial Activity. Advances in Pharmacological and Pharmaceutical Sciences. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-986298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-986298