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Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice
Joint Authors
Dey, Priyankar
Saha, Manas Ranjan
Roy Choudhuri, Sumedha
Sarkar, Indrani
Halder, Biswajit
Poddar-Sarkar, Mousumi
Sen, Arnab
Chaudhuri, Tapas Kumar
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The extracts of different parts of Nerium oleander L.
are used as antidiabetic remedy in the traditional medicinal systems of different parts of the world.
Despite these uses in ethnomedicinal system, the antihyperglycemic potentials of oleander stem (NOSE) and root (NORE) extracts have not been pharmacologically evaluated.
Therefore, we aimed at evaluating the antidiabetic ethnomedicinal claims of NOSE and NORE, primarily focusing on glucose homeostasis and associated metabolic implications.
Alloxan-treated mice with hyperglycaemia (blood glucose >200 mg/dL) were treated with oleander 70% hydromethanolic extracts (200 mg/kg) for 20 consecutive days, and the results were compared with positive control glibenclamide.
Blood glucose level was 52–65% lowered (P<0.001) in oleander treated groups, which was otherwise 4.62 times higher in diabetic mice, compared to control.
Insulin resistance was lowered 51–36% irrespective of any significant (P>0.05) changes in insulin sensitivity throughout the treatments.
Improved serum insulin remained associated with lowered glucose level (rP = −0.847 and −0.772; P<0.01).
Markers of hyperglycaemia-related hepatic glycogen, glycated haemoglobin (HbA1c), hyperlipidaemia, hepatic injury, and diabetic nephropathy were normalized as well.
Improvement of systemic intrinsic antioxidant enzymes (catalase and peroxidase) were correlated (rP = −0.952 to −0.773; P<0.01) with lower lipid peroxidation by-product malondialdehyde (MDA) in the circulation.
Principal component analysis coupled with hierarchical cluster analysis represented shift in metabolic homeostasis in diabetic mice, which was further normalized by oleander and glibenclamide treatment.
Additionally, molecular docking studies of the phenolic acids measured by HPLC with intracellular cytoprotective transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) revealed strong molecular interactions.
The results collectively support the ethnomedicine antidiabetic claims of oleander stem and root and suggest that the oleander mediated elevation of systemic antioxidant status is likely responsible for the improved glycaemic control.
American Psychological Association (APA)
Dey, Priyankar& Saha, Manas Ranjan& Roy Choudhuri, Sumedha& Sarkar, Indrani& Halder, Biswajit& Poddar-Sarkar, Mousumi…[et al.]. 2019. Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-986303
Modern Language Association (MLA)
Dey, Priyankar…[et al.]. Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice. Advances in Pharmacological and Pharmaceutical Sciences No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-986303
American Medical Association (AMA)
Dey, Priyankar& Saha, Manas Ranjan& Roy Choudhuri, Sumedha& Sarkar, Indrani& Halder, Biswajit& Poddar-Sarkar, Mousumi…[et al.]. Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice. Advances in Pharmacological and Pharmaceutical Sciences. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-986303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-986303