Probiotics for the management of neonatal hyperbilirubinemia

Abstract EN

-Background: 'n recent years, the tendency to use drugs has been increasing in the treatment of neonatal jaundice.

Several drugs have been used since then, but the effect of probiotics on serum bilirubin level (SBL) is not so clear.

This study was conducted to evaluate the effect of probiotics on SBL and the duration of phototherapy in term neonates with hyperbilirubinemia.

Objective: The aim of the work: To evaluate and assess the therapeutic effects of the probiotic substance on neonatal jaundice.

Subjects and Methodes: In this Experimental Randomized clinical trial study we studied 400 newborns with jaundice hospitalized for phototherapy in kenayate Hospital in zagazig during 5/ 2017 to 5/ 2018- Eligible neonates were Randomly divided into two groups: Intervention (n= 200), and control (n= 200) Both groups receive standard conventional phototherapy but the intervention group received 250mg lactobacillus powder with milk as a probiotic substance until hospital discharge.

The out come variable were.

TSB and the duration of phototherapy.

The data were analyzed by (SPSS version 20.0) and p value was at (<0.05) for significant, {<0.01) for high significant.

Results: TSB (out)/ on discharge after hospitalization of intervention group was a mean: 9.39± 1.35 and of control group was a mean: 9.89± 0.9, (TSB) was highly significant lower in intervention group/ on discharge with aprobiotic substance than the control group/ on discharge without aprobiotic substance.

Duration of hospitalized days needed to stay under the phototherapy treatment are of intervention group is a mean of: 4.84+ 0.62 and of control group is a mean of 5.785+ 0.801.

Conclusion: Probiotics lowered the scrum bilirubin levels of neonates with jaundice and decrease the duration of hospitalized days under phototherapy treatment Recommendation: This study recommended that we can use a probiotic substance within a plane of management of neonatal hyperbilirubinemia.

Key words: total serum bilirubin, phototherapy, probiotics.