Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri- n -Butyltin(IV) with 2-Thiobarbituric Acid
Joint Authors
Hadjikakou, Sotiris K.
Kourkoumelis, Nikolaos
Karkabounas, Spyros
Balas, Vasilios I.
Light, Mark E.
Hadjiliadis, Nick
Metsios, Apostolos K.
Hursthouse, M. B.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-01-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A novel tri-n-butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula [(n-Bu)3Sn(TBA)⋅H2O] (1) has been synthesized and characterized by elemental analysis and 119Sn-NMR and FT-IR spectroscopic techniques.
The crystal structure of complex 1 has been determined by single crystal X-ray diffraction analysis at 120(2) K.
The geometry around Sn(IV) is trigonal bipyramidal.
Three n-butyl groups and one oxygen atom from a deprotonated 2-thiobarbituric ligand are bonded to the metal center.
The geometry is completed with one oxygen from a water molecule.
Compound 1 exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis.
In addition, the inhibition caused by 1, in the rate of lipoxygenase (LOX) catalyzed oxidation reaction of linoleic acid to hyperoxolinoleic acid, has been also kinetically and theoretically studied.
The results are compared to that of cisplatin.
American Psychological Association (APA)
Balas, Vasilios I.& Hadjikakou, Sotiris K.& Hadjiliadis, Nick& Kourkoumelis, Nikolaos& Light, Mark E.& Hursthouse, M. B.…[et al.]. 2008. Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri- n -Butyltin(IV) with 2-Thiobarbituric Acid. Bioinorganic Chemistry and Applications،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-987752
Modern Language Association (MLA)
Balas, Vasilios I.…[et al.]. Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri- n -Butyltin(IV) with 2-Thiobarbituric Acid. Bioinorganic Chemistry and Applications No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-987752
American Medical Association (AMA)
Balas, Vasilios I.& Hadjikakou, Sotiris K.& Hadjiliadis, Nick& Kourkoumelis, Nikolaos& Light, Mark E.& Hursthouse, M. B.…[et al.]. Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri- n -Butyltin(IV) with 2-Thiobarbituric Acid. Bioinorganic Chemistry and Applications. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-987752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-987752