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Biomarkers and Mechanisms of FANCD2 Function
Joint Authors
Kachnic, Lisa A.
Purschke, Martin
Li, Li
Luo, Chen-Mei
Willers, Henning
Powell, Simon N.
Held, Kathryn D.
Borgmann, Kerstin
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Genetic or epigenetic inactivation of the pathway formed by the Fanconi anemia (FA) and BRCA1 proteins occurs in several cancer types, making the affected tumors potentially hypersensitive to DNA cross-linkers and other chemotherapeutic agents.
It has been proposed that the inability of FA/BRCA-defective cells to form subnuclear foci of effector proteins, such as FANCD2, can be used as a biomarker to aid individualization of chemotherapy.
We show that FANCD2 inactivation not only renders cells sensitive to cross-links, but also oxidative stress, a common effect of cancer therapeutics.
Oxidative stress sensitivity does not correlate with FANCD2 or RAD51 foci formation, but associates with increased γH2AX foci levels and apoptosis.
Therefore, FANCD2 may protect cells against cross-links and oxidative stress through distinct mechanisms, consistent with the growing notion that the pathway is not linear.
Our data emphasize the need for multiple biomarkers, such as γH2AX, FANCD2, and RAD51, to capture all pathway activities.
American Psychological Association (APA)
Willers, Henning& Kachnic, Lisa A.& Luo, Chen-Mei& Li, Li& Purschke, Martin& Borgmann, Kerstin…[et al.]. 2008. Biomarkers and Mechanisms of FANCD2 Function. BioMed Research International،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-987806
Modern Language Association (MLA)
Willers, Henning…[et al.]. Biomarkers and Mechanisms of FANCD2 Function. BioMed Research International No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-987806
American Medical Association (AMA)
Willers, Henning& Kachnic, Lisa A.& Luo, Chen-Mei& Li, Li& Purschke, Martin& Borgmann, Kerstin…[et al.]. Biomarkers and Mechanisms of FANCD2 Function. BioMed Research International. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-987806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-987806