An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots
Joint Authors
Berry, Leslie R.
Mewhort-Buist, Tracy Anne
Smith, Lesley J.
Chan, Anthony K. C.
Source
Biochemistry Research International
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Clotting blood contains fibrin-bound thrombin, which is a major source of procoagulant activity leading to clot extension and further activation of coagulation.
When bound to fibrin, thrombin is protected from inhibition by antithrombin (AT) + heparin but is neutralized when AT and heparin are covalently linked (ATH).
Here, we report the surprising observation that, rather than yielding an inert complex, thrombin-ATH formation converts clots into anticoagulant surfaces that effectively catalyze inhibition of thrombin in the surrounding environment.
American Psychological Association (APA)
Smith, Lesley J.& Mewhort-Buist, Tracy Anne& Berry, Leslie R.& Chan, Anthony K. C.. 2008. An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots. Biochemistry Research International،Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-987813
Modern Language Association (MLA)
Smith, Lesley J.…[et al.]. An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots. Biochemistry Research International No. 2008 (2008), pp.1-4.
https://search.emarefa.net/detail/BIM-987813
American Medical Association (AMA)
Smith, Lesley J.& Mewhort-Buist, Tracy Anne& Berry, Leslie R.& Chan, Anthony K. C.. An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots. Biochemistry Research International. 2008. Vol. 2008, no. 2008, pp.1-4.
https://search.emarefa.net/detail/BIM-987813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-987813