Liver X Receptor Agonists Inhibit the Phospholipid Regulatory Gene CTP: Phosphoethanolamine Cytidylyltransferase-Pcyt2

Joint Authors

Zhu, Lin
Bakovic, Marica

Source

Biochemistry Research International

Issue

Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2008-04-13

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Chemistry

Abstract EN

Metabolic pulse-chase experiments demonstrated that 25-hydroxycholesterol (25-OH), the endogenous activator of the liver X receptor (LXR), significantly reduced the biosynthesis of phosphatidylethanolamine via CDP-ethanolamine (Kennedy) pathway at the step catalyzed by CTP: phosphoethanolamine cytidylyltransferase (Pcyt2).

In the mouse embryonic fibroblasts C3H10T1/2, the LXR synthetic agonist TO901317 lowered Pcyt2 promoter-luciferase activity in a concentration-dependent manner.

Furthermore, 25-OH and TO901317 reduced mouse Pcyt2 mRNA and protein levels by 35–60%.

The inhibitory effects of oxysterols and TO901317 on the Pcyt2 promoter function, mRNA and protein expression were conserved in the human breast cancer cells MCF-7.

These studies identify the Pcyt2 gene as a novel target whereby LXR agonists may indirectly modulate inflammatory responses and atherosclerosis.

American Psychological Association (APA)

Zhu, Lin& Bakovic, Marica. 2008. Liver X Receptor Agonists Inhibit the Phospholipid Regulatory Gene CTP: Phosphoethanolamine Cytidylyltransferase-Pcyt2. Biochemistry Research International،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-987828

Modern Language Association (MLA)

Zhu, Lin& Bakovic, Marica. Liver X Receptor Agonists Inhibit the Phospholipid Regulatory Gene CTP: Phosphoethanolamine Cytidylyltransferase-Pcyt2. Biochemistry Research International No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-987828

American Medical Association (AMA)

Zhu, Lin& Bakovic, Marica. Liver X Receptor Agonists Inhibit the Phospholipid Regulatory Gene CTP: Phosphoethanolamine Cytidylyltransferase-Pcyt2. Biochemistry Research International. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-987828

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-987828