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The Metabolism and Transplacental Transfer of Oseltamivir in the Ex Vivo Human Model
Joint Authors
Worley, Kevin C.
Roberts, Scott W.
Bawdon, Roger E.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Oseltamivir phosphate is extensively metabolized in the ex vivo human placenta model, and the transplacental passage of the metabolite oseltamivir carboxylate is incomplete.
Objective.
To evaluate the metabolism and transplacental transfer of oseltamivir (Tamiflu) in the ex vivo human placental model.
Study Design.
Perfusion studies were performed in six placentas from term, uncomplicated deliveries.
Concentrations of oseltamivir phosphate (OP) that were 5-6 fold, 20–30 fold, and 600–800 fold above the therapeutic peak were tested, as neither OP nor its active metabolite, oseltamivir carboxylate (OC), could be detected at near-therapeutic concentrations.
The transplacental transfer and accumulation of OC were assessed using the 14C antipyrine reference method.
Results.
OP was extensively metabolized to OC.
In the 4 placentas with the highest concentration of OP, OC had a mean clearance index of 0.13±0.08, suggesting that transplacental passage occurs at a relatively low rate.
Measurable fetal accumulation occurred in the two placentas with the highest initial concentrations.
Conclusions.
Oseltamivir phosphate was extensively metabolized in the ex vivo model.
Transplacental transfer of the metabolite was incomplete and accumulation was minimal.
American Psychological Association (APA)
Worley, Kevin C.& Roberts, Scott W.& Bawdon, Roger E.. 2008. The Metabolism and Transplacental Transfer of Oseltamivir in the Ex Vivo Human Model. Infectious Diseases in Obstetrics and Gynecology،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-987838
Modern Language Association (MLA)
Worley, Kevin C.…[et al.]. The Metabolism and Transplacental Transfer of Oseltamivir in the Ex Vivo Human Model. Infectious Diseases in Obstetrics and Gynecology No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-987838
American Medical Association (AMA)
Worley, Kevin C.& Roberts, Scott W.& Bawdon, Roger E.. The Metabolism and Transplacental Transfer of Oseltamivir in the Ex Vivo Human Model. Infectious Diseases in Obstetrics and Gynecology. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-987838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-987838