Effects of Subminimum Inhibitory Concentrations of Antibiotics on the Pasteurella multocida Proteome: A Systems Approach
Joint Authors
Peddinti, Divya Swetha
Lawrence, Mark L.
Burgess, Shane C.
Nanduri, Bindu
Source
International Journal of Genomics
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To identify key regulators of subminimum inhibitory concentration (sub-MIC) antibiotic response in the Pasteurella multocida proteome, we applied systems approaches.
Using 2D-LC-ESI-MS2, we achieved 53% proteome coverage.
To study the differential protein expression in response to sub-MIC antibiotics in the context of protein interaction networks, we inferred P.
multocida Pm70 protein interaction network from orthologous proteins.
We then overlaid the differential protein expression data onto the P.
multocida protein interaction network to study the bacterial response.
We identified proteins that could enhance antimicrobial activity.
Overall compensatory response to antibiotics was characterized by altered expression of proteins involved in purine metabolism, stress response, and cell envelope permeability.
American Psychological Association (APA)
Nanduri, Bindu& Lawrence, Mark L.& Peddinti, Divya Swetha& Burgess, Shane C.. 2008. Effects of Subminimum Inhibitory Concentrations of Antibiotics on the Pasteurella multocida Proteome: A Systems Approach. International Journal of Genomics،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-987867
Modern Language Association (MLA)
Nanduri, Bindu…[et al.]. Effects of Subminimum Inhibitory Concentrations of Antibiotics on the Pasteurella multocida Proteome: A Systems Approach. International Journal of Genomics No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-987867
American Medical Association (AMA)
Nanduri, Bindu& Lawrence, Mark L.& Peddinti, Divya Swetha& Burgess, Shane C.. Effects of Subminimum Inhibitory Concentrations of Antibiotics on the Pasteurella multocida Proteome: A Systems Approach. International Journal of Genomics. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-987867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-987867