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Protein Coding Gene Nucleotide Substitution Pattern in the Apicomplexan Protozoa Cryptosporidium parvum and Cryptosporidium hominis
Joint Authors
Ge, Guangtao
Feng, Xiaochuan
Cowen, Lenore
Widmer, Giovanni
Source
International Journal of Genomics
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cryptosporidium parvum and C.
hominis are related protozoan pathogens which infect the intestinal epithelium of humans and other vertebrates.
To explore the evolution of these parasites, and identify genes under positive selection, we performed a pairwise whole-genome comparison between all orthologous protein coding genes in C.
parvum and C.
hominis.
Genome-wide calculation of the ratio of nonsynonymous versus synonymous nucleotide substitutions (dN/dS) was performed to detect the impact of positive and purifying selection.
Of 2465 pairs of orthologous genes, a total of 27 (1.1%) showed a high ratio of nonsynonymous substitutions, consistent with positive selection.
A majority of these genes were annotated as hypothetical proteins.
In addition, proteins with transmembrane and signal peptide domains are significantly more frequent in the high dN/dS group.
American Psychological Association (APA)
Ge, Guangtao& Cowen, Lenore& Feng, Xiaochuan& Widmer, Giovanni. 2008. Protein Coding Gene Nucleotide Substitution Pattern in the Apicomplexan Protozoa Cryptosporidium parvum and Cryptosporidium hominis. International Journal of Genomics،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-987876
Modern Language Association (MLA)
Ge, Guangtao…[et al.]. Protein Coding Gene Nucleotide Substitution Pattern in the Apicomplexan Protozoa Cryptosporidium parvum and Cryptosporidium hominis. International Journal of Genomics No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-987876
American Medical Association (AMA)
Ge, Guangtao& Cowen, Lenore& Feng, Xiaochuan& Widmer, Giovanni. Protein Coding Gene Nucleotide Substitution Pattern in the Apicomplexan Protozoa Cryptosporidium parvum and Cryptosporidium hominis. International Journal of Genomics. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-987876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-987876